Egg consumption and risks of all-cause and cause-specific mortality: a dose-response meta-analysis of prospective cohort studies
Yang PF, Wang CR, Hao FB, Peng Y, Wu JJ, Sun WP, Hu JJ, Zhong GC
Nutrition reviews · 12 citations
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- Meta-analysis (indexed by PubMed)
- Studied in
- People
- Main outcome
- Clinical events such as disease or death
- Intake measured by
- Not stated
Who paid for it
- Funding
- Funding not disclosed
Publication
- Published
- 2022-01-14 · Nutr Rev · vol. 80 · issue 7 · pp. 1739–1754
- Publisher
- Oxford University Press
- Cited
- 14 citations · more than 62% of similar papers · 0.8× the field average
- References
- 60 works
- Access
- Paywalled
- Research areas
- Nutritional Studies and Diet · Antioxidant Activity and Oxidative Stress · Consumer Attitudes and Food Labeling
- Keywords
- Medicine, Hazard ratio, Context (archaeology), Prospective cohort study, Meta-analysis, Population, Cohort study, Internal medicine, Relative risk, Demography, Confidence interval, Environmental health, Biology
- MeSH
- humans, neoplasms, cardiovascular diseases, diet, cause of death, risk factors, prospective studies
8 authors
From CN
- Pengfei YangDalian Medical University; Second Affiliated Hospital of Chongqing Medical University; Chongqing Medical University
- Chunrui WangDalian Medical University; Second Affiliated Hospital of Chongqing Medical University; Chongqing Medical University
- Fa‐Bao HaoQingdao University; Qingdao Women and Children's Hospital
- Yang PengChengdu Fifth People's Hospital
- Jingjing WuChongqing Public Health Medical Center; Chongqing Medical University
- Weiping SunDalian Medical University; Second Affiliated Hospital of Chongqing Medical University; Chongqing Medical University
Abstract
Context
Current dietary guidelines recommend eggs as a part of a healthy diet. However, whether egg consumption is associated with risk of mortality remains controversial. Moreover, the dose-response association of egg consumption with risk of mortality has not been determined.
Objective
To determine the potential dose-response association of egg consumption with risk of mortality in the general population.
Data sources
The PubMed and Embase databases were searched for publications meeting eligibility criteria through November 2021.
Data extraction
Required data were extracted by 1 reviewer and then checked for accuracy by another reviewer. A random-effects dose-response meta-regression model was used to calculate the pooled risk estimates. A restricted cubic spline model was used to test nonlinearity. The certainty of evidence was assessed using the GRADE system.
Data analysis
Nineteen prospective cohort studies, involving 1 737 893 participants, were included. The pooled hazard ratios for an increase of 1 egg/d were 1.08 (95%CI, 1.01-1.15) for all-cause mortality, 1.07 (95%CI, 0.97-1.18) for cardiovascular disease-caused mortality, and 1.16 (95%CI, 1.04-1.30) for cancer-caused mortality. The certainty of evidence for these observations was rated as very low. Nonlinear dose-response associations were found for egg consumption and all-cause, cardiovascular disease-caused, and cancer-caused mortality. Moreover, the positive association between egg consumption and all-cause mortality was more pronounced in studies with adjustment for blood cholesterol-related covariates than those without (Pinteraction = 0.011).
Conclusions
Greater amount of egg consumption confers higher risks of death from all causes, cardiovascular disease, and canc er in a nonlinear dose-response pattern. These findings should be treated with caution and need to be confirmed by future studies.
Abstract via Europe PMC. Copyright remains with the authors or publisher.
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