Associations Between Unprocessed Red Meat and Processed Meat With Risk of Recurrence and Mortality in Patients With Stage III Colon Cancer
Van Blarigan EL, Ou FS, Bainter TM, Fuchs CS, Niedzwiecki D, Zhang S, Saltz LB, Mayer RJ, Hantel A, Benson AB, Atienza D, Messino M, Kindler HL, Venook AP, Ogino S, Sanoff HK, Giovannucci EL, Ng K, Meyerhardt JA
JAMA network open · 9 citations
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- Cohort study (indexed by PubMed)
- Studied in
- People
- Main outcome
- Clinical events such as disease or death
- Intake measured by
- Food frequency questionnaire
Who paid for it
- Funding
- Independent funding
- Government
- National Cancer Institute
- Government
- NCI NIH HHS
- Grants
- National Cancer Institute (UG1CA233327); National Cancer Institute (K07 CA197077); National Cancer Institute (R01CA118553); National Cancer Institute (U10 CA180821); National Cancer Institute (U10-CA180888); National Cancer Institute (U10CA180836); National Cancer Institute (UG1 CA233180); National Cancer Institute (U10 CA180867); National Cancer Institute (U10 CA180791); National Cancer Institute (R35CA197735); National Cancer Institute (UG1CA233290); National Cancer Institute (U10CA077651); National Cancer Institute (U10CA041287); National Cancer Institute (UG1 CA233373); National Cancer Institute (U10CA180820); National Cancer Institute (U10-CA180882); National Cancer Institute (U10 CA138561); National Cancer Institute (U10CA045808); National Cancer Institute (U10 CA032291); National Cancer Institute (UG1 CA233337); National Cancer Institute (UG1CA189858); National Cancer Institute (#P30-CA008748)
Based on 2 listed funder(s).
Publication
- Published
- 2022-02-22 · JAMA Netw Open · vol. 5 · issue 2 · p. e220145
- Publisher
- American Medical Association
- Cited
- 15 citations · more than 89% of similar papers · 2.5× the field average
- References
- 22 works
- Access
- Open access (journal) · CC-BY
- Research areas
- Nutritional Studies and Diet · Colorectal Cancer Screening and Detection · Agriculture Sustainability and Environmental Impact
- Keywords
- Medicine, Red meat, Colorectal cancer, Cancer, Hazard ratio, Internal medicine, Prospective cohort study, Quartile, Surgery, Confidence interval, Pathology
- MeSH
- humans, colonic neoplasms, neoplasm recurrence, local, diet, proportional hazards models, prospective studies, aged, middle aged, female, male, red meat
19 authors
From US
- Erin Lynn Van Blarigan · correspondingUniversity of California, San Francisco
- Fang‐Shu OuMayo Clinic
- Tiffany M. BainterMayo Clinic
- Charles S. FuchsYale Cancer Center
- Donna NiedzwieckiDuke University
- Sui ZhangJohns Hopkins University
Abstract
Importance
The American Cancer Society and American Institute for Cancer Research recommend that cancer survivors limit intake of red and processed meats. This recommendation is based on consistent associations between red and processed meat intake and cancer risk, particularly risk of colorectal cancer, but fewer data are available on red and processed meat intake after cancer diagnosis.
Objectives
To examine whether intake of unprocessed red meat or processed meat is associated with risk of cancer recurrence or mortality in patients with colon cancer.
Design, setting, and participants
This prospective cohort study used data from participants with stage III colon cancer enrolled in the Cancer and Leukemia Group B (CALGB 89803/Alliance) trial between 1999 and 2001. The clinical database for this analysis was frozen on November 9, 2009; the current data analyses were finalized in December 2021.
Exposures
Quartiles of unprocessed red meat and processed meat intake assessed using a validated food frequency questionnaire during and 6 months after chemotherapy.
Main outcomes and measures
Hazard ratios (HRs) and 95% CIs for risk of cancer recurrence or death and all-cause mortality.
Results
This study was conducted among 1011 patients with stage III colon cancer. The median (IQR) age at enrollment was 60 (51-69) years, 442 patients (44%) were women, and 899 patients (89%) were White. Over a median (IQR) follow-up period of 6.6 (1.9-7.5) years, we observed 305 deaths and 81 recurrences without death during follow-up (386 events combined). Intake of unprocessed red meat or processed meat after colon cancer diagnosis was not associated with risk of recurrence or mortality. The multivariable HRs comparing the highest vs lowest quartiles for cancer recurrence or death were 0.84 (95% CI, 0.58-1.23) for unprocessed red meat and 1.05 (95% CI, 0.75-1.47) for processed meat. For all-cause mortality, the corresponding HRs were 0.71 (95% CI, 0.47-1.07) for unprocessed red meat and 1.04 (95% CI, 0.72-1.51) for processed meat.
Conclusions and relevance
In this cohort study, postdiagnosis intake of unprocessed red meat or processed meat was not associated with risk of recurrence or death among patients with stage III colon cancer.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY).
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