Randomized controlled trial for time-restricted eating in healthy volunteers without obesity
Xie Z, Sun Y, Ye Y, Hu D, Zhang H, He Z, Zhao H, Yang H, Mao Y
Nature communications · 226 citations
How it was studied
- Design
- Randomized controlled trial (indexed by PubMed)
- Studied in
- People
- Main outcome
- Health markers and function
Who paid for it
- Funding
- Independent funding
- University or hospital
- Chinese Academy of Medical Sciences
- Grants
- Chinese Academy of Medical Sciences (CIFMS No.2016-I2M-1-001)
Based on 1 listed funder(s) and full-text disclosure statement.
Publication
- Published
- 2022-02-22 · Nat Commun · vol. 13 · issue 1 · p. 1003
- Publisher
- Nature Portfolio
- Cited
- 278 citations · more than 100% of similar papers · 27.4× the field average
- Impact
- Top 10% most cited in its field
- References
- 77 works
- Access
- Open access (journal) · CC-BY
- Research areas
- Dietary Effects on Health · Circadian rhythm and melatonin · Sleep and related disorders
- Keywords
- Randomized controlled trial, Obesity, Medicine, Time trial, Internal medicine
- MeSH
- humans, insulin resistance, obesity, glucose, fasting, healthy volunteers
9 authors
From CN
- Zhibo XieChinese Academy of Medical Sciences & Peking Union Medical College; Peking Union Medical College Hospital
- Yuning SunChinese Academy of Medical Sciences & Peking Union Medical College; Peking Union Medical College Hospital
- Yuqian YeChinese Academy of Medical Sciences & Peking Union Medical College; Peking Union Medical College Hospital
- Dandan HuSun Yat-sen University; Chinese Academy of Medical Sciences & Peking Union Medical College; Peking Union Medical College Hospital; Sun Yat-sen University Cancer Center
- Hua ZhangChinese Academy of Medical Sciences & Peking Union Medical College; Peking Union Medical College Hospital
- Zhangyuting HeChinese Academy of Medical Sciences & Peking Union Medical College; Peking Union Medical College Hospital
Abstract
Time-restricted feeding (TRF) improves metabolic health. Both early TRF (eTRF, food intake restricted to the early part of the day) and mid-day TRF (mTRF, food intake restricted to the middle of the day) have been shown to have metabolic benefits. However, the two regimens have yet to be thoroughly compared. We conducted a five-week randomized trial to compare the effects of the two TRF regimens in healthy individuals without obesity (ChiCTR2000029797). The trial has completed. Ninety participants were randomized to eTRF (n=30), mTRF (n=30), or control groups (n=30) using a computer-based random-number generator. Eighty-two participants completed the entire five-week trial and were analyzed (28 in eTRF, 26 in mTRF, 28 in control groups). The primary outcome was the change in insulin resistance. Researchers who assessed the outcomes were blinded to group assignment, but participants and care givers were not. Here we show that eTRF was more effective than mTRF at improving insulin sensitivity. Furthermore, eTRF, but not mTRF, improved fasting glucose, reduced total body mass and adiposity, ameliorated inflammation, and increased gut microbial diversity. No serious adverse events were reported during the trial. In conclusion, eTRF showed greater benefits for insulin resistance and related metabolic parameters compared with mTRF. Clinical Trial Registration URL: http://www.chictr.org.cn/showproj.aspx?proj=49406 .
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY).
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