Seasonal dynamic of cholecalciferol (D3) and anti-Muellerian hormone (AMH) with impact on ovarian response and IVF/ICSI
Rogenhofer N, Jeschke U, von Schönfeldt V, Mahner S, Thaler CJ
Archives of gynecology and obstetrics · 2 citations
How it was studied
- Design
- Cohort study (classified by our AI screen)
- Studied in
- People
- Main outcome
- Health markers and function
Who paid for it
- Funding
- Independent funding
- University or hospital
- Universitätsklinik München
Based on 1 listed funder(s) and full-text disclosure statement.
Publication
- Published
- 2022-02-27 · Arch Gynecol Obstet · vol. 306 · issue 1 · pp. 219–228
- Publisher
- Springer Science+Business Media
- Cited
- 7 citations · more than 70% of similar papers · 0.7× the field average
- References
- 46 works
- Access
- Open access (hybrid journal) · CC-BY
- Research areas
- Ovarian function and disorders · Reproductive Physiology in Livestock · Reproductive tract infections research
- Keywords
- Medicine, Quartile, Context (archaeology), Physiology, Hormone, Pregnancy, Andrology, Gynecology, Internal medicine, Endocrinology, Biology
- MeSH
- humans, cholecalciferol, fertilization in vitro, sperm injections, intracytoplasmic, ovulation induction, pregnancy rate, retrospective studies, seasons, pregnancy, female, anti-mullerian hormone
5 authors
From DE
- Nina Rogenhofer · correspondingLMU Klinikum; Ludwig-Maximilians-Universität München
- Udo JeschkeUniversity Hospital Augsburg; LMU Klinikum; Ludwig-Maximilians-Universität München
- Viktoria von SchönfeldtLMU Klinikum; Ludwig-Maximilians-Universität München
- Sven� MahnerLMU Klinikum; Ludwig-Maximilians-Universität München
- Christian ThalerLMU Klinikum; Ludwig-Maximilians-Universität München
Abstract
Objective
Recent studies revealed intriguing associations between cholecalciferol (D3) and reproductive functions. Seasonal changes of D3 concentrations are well known; however, they are not always considered in the context of reproductive functions. In this study, we analyzed D3 serum concentration in IVF/ICSI patients with respect to seasonal 3-month quartiles and anti-Muellerian hormone (AMH) referring to the impact on Assisted Reproductive Technologies (ART) outcome.
Materials and research methods
We studied 469 female patients, presenting between 2012 and 2018 for ART treatment in our fertility center. D3 as well as the AMH serum concentrations were measured at the beginning of the follicle stimulation (days 3-5 of menstrual cycles). Results were evaluated with respect to seasonal quartiles and outcome of the ART cycles.
Results
D3 concentrations showed significant fluctuations within annual quartiles with a pronounced peak in August-October and a minimum in February-April (26.0 vs. 20.5 mg/dl; p < 0.0001). Similar seasonal dynamics were found for AMH (2.98 vs. 1.78 ng/ml; p = 0.010) and these were associated with significantly shorter stimulation periods during August-October (11.29 vs. 12.12 days; p = 0.042), higher number of fertilized oocytes between August and October (6.23 vs. 4.97; p = 0.05) along with a trend towards higher numbers of cumulus-oocyte complexes. However, no such differences were found for the numbers of MII oocytes or pregnancy rates.
Conclusion
Our data indicate seasonal 3-month quartile variations of AMH concentrations and characteristics of ART, such as days of ovarian stimulation and number of fertilized oocytes. Highest AMH concentrations were found between August and October and this quartile was associated with highest D3 concentrations.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY).
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