Cholecalciferol level and its impact on COVID-19 patients
Saeed MAM, Mohamed AH, Owaynat AH
The Egyptian journal of internal medicine · 3 citations
How it was studied
- Design
- Cohort study (classified by our AI screen)
- Studied in
- People
- Main outcome
- Clinical events such as disease or death
Who paid for it
- Funding
- Independent funding
Based on full-text disclosure statement.
Publication
- Published
- 2022-02-21 · Egypt J Intern Med · vol. 34 · issue 1 · p. 23
- Publisher
- Springer Nature
- Cited
- 6 citations · more than 69% of similar papers · 0.8× the field average
- References
- 50 works
- Access
- Open access (free to publish) · CC-BY
- Research areas
- Vitamin D Research Studies · COVID-19 Clinical Research Studies · Vitamin C and Antioxidants Research
- Keywords
- Cholecalciferol, Vitamin D and neurology, Medicine, vitamin D deficiency, Vitamin, Coronavirus disease 2019 (COVID-19), Internal medicine, Gastroenterology, Pediatrics, Disease, Infectious disease (medical specialty)
3 authors
From EG
- Mohammed Abdel Monem Saeed · correspondingHelwan University
- Alaa Hussein MohamedHelwan University
- Ahmed Hassan OwaynatHelwan University
Abstract
Background
Cholecalciferol is an important nutrient and essential to build body, maintain strong bones, and improves immunity.The main source for vitamin D is the body's skin which absorbs the sun's ultraviolet rays and convert them into vitamin D; at the same time, deficiency can occur or people may not get enough supplementation; this occurs mainly in old age, not taking healthy food, or have darker skin, and this deficient cases can raise the risk of severe COVID-19 if infected.Vitamin D boosts immunity and decreases inflammation. Poorer outcome of corona virus-disease (COVID-19) has been suggested to be due to vitamin D deficiency.We suggested to find the effect of cholecalciferol levels 25-hydroxy vitamin D (25 OHD) on the severity and mortality in patients suffering from COVID-19.
Methods
Our study is a prospective following of 414 patients admitted in Helwan University Hospitals in the period of June 2020 till October 2021 for severely symptomatic. COVID-19 patients with median of age 54.55 ± 14.27, with a definite range of APACHE II score ranging from 15 to 19 where we measured vitamin D3 level (cholecalciferol level), correlating the assay level to the inflammatory cytokine storm markers on admission, on the fifth day and after 10 days also the level of vitamin D3 was correlated to the length of stay mechanical ventilation days and mortality.
Results
Lower level of vitamin D3 on admission was strongly evident in patients with severely symptomatic and in mortality of COVID-19 patients 58.25 ± 24.59 nmol/L when compared with patients who survived 103.97 ± 36.14 nmol/L with P value 3 on admission with the level of the inflammatory cytokine storm markers on admission, on fifth day from admission and on the tenth day, it shows a strong inverse correlation between vitamin D3 level on admission and ferritin level on fifth day ρ-0.739 p value P value p value p value this also evident on the D-dimer level on the tenth day ρ-0.889 with p value P value P value 3 it shows a strong inverse correlation with a highly significant p value. ρ-0.887, P value p value 3 level (cholecalciferol) on admission with ρ-0.753, p P p value p P 3 to predict mortality (RR 0.865, 95% CI 0.828-0.896, P 3 < 60 nmol/L, regardless of other factors like age, gender, and presence of other co-morbidities.
Conclusion
Low level of cholecalciferol was strongly inversely correlated with cytokine storm markers and independent predictor of severity and mortality in COVID-19 patients.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY).
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