Association of Serum 25-Hydroxyvitamin D With Cardiovascular Outcomes and All-Cause Mortality in Individuals With Prediabetes and Diabetes: Results From the UK Biobank Prospective Cohort Study
Zhang P, Guo D, Xu B, Huang C, Yang S, Wang W, Liu W, Deng Y, Li K, Liu D, Lin J, Wei X, Huang Y, Zhang H
Diabetes care · 63 citations
How it was studied
- Design
- Cohort study (indexed by PubMed)
- Studied in
- People
- Main outcome
- Clinical events such as disease or death
Who paid for it
- Funding
- Independent funding
- Government
- National Natural Science Foundation of China
- University or hospital
- Southern Medical University
- University or hospital
- Nanfang Hospital
- Grants
- Southern Medical University (LC2019ZD010); National Natural Science Foundation of China (81970736); Southern Medical University (2018YFA0800404); National Natural Science Foundation of China (LC2019ZD010); National Natural Science Foundation of China (2019CR022); Southern Medical University (2019CR022); Southern Medical University (81970736)
Based on 3 listed funder(s).
Publication
- Published
- 2022-02-28 · Diabetes Care · vol. 45 · issue 5 · pp. 1219–1229
- Publisher
- American Diabetes Association
- Cited
- 77 citations · more than 99% of similar papers · 8.8× the field average
- Impact
- Top 10% most cited in its field
- References
- 44 works
- Access
- Open access (hybrid journal) · OTHER-OA
- Research areas
- Vitamin D Research Studies · Bone health and osteoporosis research · Estrogen and related hormone effects
- Keywords
- Medicine, Prediabetes, Hazard ratio, Internal medicine, Diabetes mellitus, Proportional hazards model, Prospective cohort study, Cohort study, Population, Cohort, Type 2 diabetes, Endocrinology, Confidence interval
- MeSH
- humans, cardiovascular diseases, coronary disease, diabetes mellitus, prediabetic state, vitamin d, risk factors, cohort studies, prospective studies, adult, biological specimen banks, heart failure, stroke, united kingdom
14 authors
From CN
- Peizhen Zhang · correspondingKey Laboratory of Guangdong Province; Nanfang Hospital; Southern Medical University
- Dan GuoKey Laboratory of Guangdong Province; Nanfang Hospital; Southern Medical University
- Bingyan XuKey Laboratory of Guangdong Province; Nanfang Hospital; Southern Medical University
- Chensihan HuangKey Laboratory of Guangdong Province; Nanfang Hospital; Southern Medical University
- Shunyu YangKey Laboratory of Guangdong Province; Nanfang Hospital; Southern Medical University
- Weiwei WangKey Laboratory of Guangdong Province; Nanfang Hospital; Southern Medical University
Abstract
Objective
To examine the associations of circulating 25-hydroxyvitamin D (25[OH]D) concentrations with cardiovascular disease (CVD) and all-cause mortality in individuals with prediabetes and diabetes from the large population-based UK Biobank cohort study.
Research design and methods
A total of 67,789 individuals diagnosed with prediabetes and 24,311 with diabetes who had no CVD or cancer at baseline were included in the current study. Serum 25(OH)D concentrations were measured at baseline. Cox proportional hazard models were used to calculate hazard ratios (HRs) and 95% CIs for cardiovascular outcomes and mortality after 10-14 years.
Results
After multivariable adjustment, higher serum 25(OH)D levels were significantly and nonlinearly associated with lower risk of cardiovascular outcomes and all-cause mortality among participants with prediabetes and diabetes (all P nonlinearity < 0.05). Compared with those in the lowest category of 25(OH)D levels (<25 nmol/L), participants with prediabetes in the highest category of 25(OH)D levels (≥75 nmol/L) had a significant association with lower risk of cardiovascular events (HR 0.78; 95% CI 0.71-0.86), coronary heart disease (CHD) (HR 0.79; 95% CI 0.71-0.89), heart failure (HR 0.66; 95% CI 0.54-0.81), stroke (HR 0.75; 95% CI 0.61-0.93), CVD mortality (HR 0.43; 95% CI 0.32-0.59), and all-cause mortality (HR 0.66; 95% CI 0.58-0.75). Likewise, these associations with cardiovascular events, CHD, heart failure, CVD mortality, and all-cause mortality were observed among participants with diabetes, except for stroke.
Conclusions
These findings highlight the importance of monitoring and correcting vitamin D deficiency in the prevention of CVD and mortality among adults with prediabetes and diabetes.
Abstract via Europe PMC. Copyright remains with the authors or publisher.
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