Long-term cholecalciferol supplementation in hemodialysis patients: Effects on mineral metabolism, inflammation, and cardiac parameters
Matias PJ, Laranjinha I, Ávila G, Azevedo A, Jorge C, Ferreira C, Aires I, Amaral T, Gil C, Ferreira A
Seminars in dialysis · 5 citations
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- Cohort study (indexed by PubMed)
- Studied in
- People
- Main outcome
- Health markers and function
Who paid for it
- Funding
- Funding not disclosed
Publication
- Published
- 2022-03-09 · Semin Dial · vol. 36 · issue 1 · pp. 29–36
- Publisher
- Wiley
- Cited
- 6 citations · more than 69% of similar papers · 0.8× the field average
- References
- 42 works
- Access
- Paywalled
- Research areas
- Vitamin D Research Studies · Parathyroid Disorders and Treatments · Magnesium in Health and Disease
- Keywords
- Medicine, Internal medicine, Cholecalciferol, Endocrinology, Vitamin D and neurology, Natriuretic peptide, Hemodialysis, Bone remodeling, vitamin D deficiency, Kidney disease, Calcium metabolism, Inflammation, Calcium, Heart failure
- MeSH
- humans, vitamin d deficiency, inflammation, minerals, cholecalciferol, vitamins, vitamin d, renal dialysis, prospective studies, dietary supplements
10 authors
From PT
- Patrícia Matias · correspondingHospital Vila Franca de Xira; Universidade Nova de Lisboa
- Ivo LaranjinhaHospital Vila Franca de Xira
- Gonçalo ÁvilaHospital Vila Franca de Xira
- Ana AzevedoHospital Vila Franca de Xira
- Cristina Rego de Freitas Mendes JorgeHospital Vila Franca de Xira
- Ana Carina FerreiraHospital Vila Franca de Xira; Universidade Nova de Lisboa
Abstract
Background
Low levels of 25-hydroxyvitamin D [25(OH)D] are frequent in chronic kidney disease and are associated with adverse outcomes. The aim of this 5-year prospective study was to evaluate the effects of cholecalciferol supplementation on mineral metabolism, inflammation and cardiac parameters in hemodialysis (HD) patients.
Methods
The study included 97 patients. Cholecalciferol was given after HD according to 25(OH)D baseline levels measured twice (end of winter and of summer). The 25(OH)D levels, circulating bone metabolism, inflammation parameters, brain natriuretic peptide (BNP), pulse pressure (PP), and left ventricular mass index (LVMI) were evaluated before and after supplementation.
Results
There was a significant increase in 25(OH)D levels after supplementation (p < 0.001); however, serum calcium (p = 0.02), phosphorus (p = 0.018), and iPTH (p = 0.03) were decreased. Magnesium levels increased during the study (p = 0.03). A reduction in the number of patients under active vitamin D (p < 0.001) and in the dose and number of patients treated with darbepoetin (p = 0.02) was observed. Serum albumin increased (p < 0.001), and C-reactive protein decreased (p = 0.01). BNP (p < 0.001), PP (p = 0.007), and LVMI (p = 0.02) were significantly reduced after supplementation.
Conclusions
Long-term cholecalciferol supplementation allowed correction of 25(OH)D deficiency, improved mineral metabolism with less use of active vitamin D, attenuated inflammation, reduced the dose of the erythropoiesis-stimulating agent, and improved cardiac dysfunction.
Abstract via Europe PMC. Copyright remains with the authors or publisher.
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