Plasma Metabolite Profiles of Red Meat, Poultry, and Fish Consumption, and Their Associations with Colorectal Cancer Risk
Wang F, Chandler PD, Zeleznik OA, Wu K, Wu Y, Yin K, Song R, Avila-Pacheco J, Clish CB, Meyerhardt JA, Zhang X, Song M, Ogino S, Lee IM, Eliassen AH, Liang L, Smith-Warner SA, Willett WC, Giovannucci EL
Nutrients · 17 citations
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- Case-control study (classified by our AI screen)
- Studied in
- People
- Main outcome
- Clinical events such as disease or death
- Intake measured by
- Food frequency questionnaire
Who paid for it
- Funding
- Independent funding
- Government
- National Institutes of Health
- Government
- National Cancer Institute
- Government
- National Institute of Diabetes and Digestive and Kidney Diseases
- Government
- NIH HHS
- Government
- NCI NIH HHS
- Government
- NIDDK NIH HHS
- Grants
- National Cancer Institute (P01 CA087969); National Institute of Diabetes and Digestive and Kidney Diseases (R01DK120870); National Institute of Diabetes and Digestive and Kidney Diseases (R01-DK-119268); National Institutes of Health (U01-CA167552); National Institutes of Health (R01-CA67262); National Institutes of Health (R01 CA49449); National Institutes of Health (P01 CA 87969); National Institutes of Health (U01-CA176726); National Institutes of Health (R01DK120870); National Institutes of Health (UM1‐CA‐186107)
Based on 6 listed funder(s).
Publication
- Published
- 2022-02-25 · Nutrients · vol. 14 · issue 5 · p. 978
- Publisher
- Multidisciplinary Digital Publishing Institute
- Cited
- 22 citations · more than 93% of similar papers · 3.5× the field average
- Impact
- Top 10% most cited in its field
- References
- 41 works
- Access
- Open access (journal) · CC-BY
- Research areas
- Nutritional Studies and Diet · Metabolomics and Mass Spectrometry Studies · Fatty Acid Research and Health
- Keywords
- Metabolite, Red meat, Medicine, White meat, Logistic regression, Colorectal cancer, Food group, Food science, Internal medicine, Environmental health, Physiology, Biology, Cancer, Pathology
- MeSH
- animals, poultry, colorectal neoplasms, logistic models, follow-up studies, female, red meat
19 authors
From US
- Fenglei WangHarvard University
- Paulette D. ChandlerBrigham and Women's Hospital; Harvard University
- Oana Alina ZeleznikBrigham and Women's Hospital; Harvard University
- Kana WuHarvard University
- You WuHarvard University
- Kanhua YinHarvard University
Abstract
Background
Red and processed meat consumption has been consistently associated with increased risk of colorectal cancer (CRC), but the association for fish intake is unclear. Evidence using objective dietary assessment approaches to evaluate these associations is sparse.
Objectives
We aim to investigate the plasma metabolite profiles related to red meat, poultry, and fish consumption and examine their associations with CRC risk.
Methods
We measured plasma metabolites among 5269 participants from the Nurses' Health Study (NHS), NHSII, and Health Professionals Follow-Up study (HPFS). We calculated partial Spearman correlations between each metabolite and self-reported intake of seven red meat, poultry, and fish groups. Metabolite profile scores correlated to self-reported dietary intakes were developed using elastic net regression. Associations between self-reported intakes, metabolite profile scores, and subsequent CRC risk were further evaluated using conditional logistic regression among 559 matched (1:1) case-control pairs in NHS/HPFS and replicated among 266 pairs in Women's Health Study.
Results
Plasma metabolites, especially highly unsaturated lipids, were differentially associated with red meat and fish groups. Metabolite profile scores for each food group were significantly correlated with the corresponding self-reported dietary intake. A higher dietary intake of processed red meat was associated with a higher risk of CRC (pooled OR per 1 SD, 1.15; 95% CI: 1.03, 1.29). In contrast, higher metabolite profile scores for all fish groups, not dietary intakes, were consistently associated with a lower CRC risk: the pooled OR per 1 SD was 0.86 (95% CI: 0.78, 0.96) for total fish, 0.86 (95% CI: 0.77, 0.96) for dark meat fish, and 0.87 (95% CI: 0.78, 0.97) for canned tuna fish. No significant associations were found for other food groups.
Conclusions
Red meat and fish intake exhibited systematically different plasma metabolite profiles. Plasma metabolite profile of fish intake was inversely associated with CRC risk.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY).
Community trust
Loading…
How much do you trust this study's findings?
Comments
Sign in to rate, comment on or flag this study.Sign inSomething wrong here?
Flag this study if its information, labels or funding look wrong. An editor reviews every flag.
Sign in to rate, comment on or flag this study.Sign inEducational information about published research. Not medical advice, and not a recommendation to start or stop anything.