Effect of Magnesium Supplementation on Inflammatory Parameters: A Meta-Analysis of Randomized Controlled Trials
Veronese N, Pizzol D, Smith L, Dominguez LJ, Barbagallo M
Nutrients · 68 citations
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- Meta-analysis (indexed by PubMed)
- Studied in
- People
- Main outcome
- Mechanisms only
Who paid for it
- Funding
- Independent funding
Based on full-text disclosure statement.
Publication
- Published
- 2022-02-05 · Nutrients · vol. 14 · issue 3 · p. 679
- Publisher
- Multidisciplinary Digital Publishing Institute
- Cited
- 88 citations · more than 96% of similar papers · 3.5× the field average
- Impact
- Top 10% most cited in its field
- References
- 57 works
- Access
- Open access (journal) · CC-BY
- Research areas
- Magnesium in Health and Disease · Biomarkers in Disease Mechanisms · Parathyroid Disorders and Treatments
- Keywords
- Placebo, Randomized controlled trial, Medicine, Meta-analysis, Internal medicine, C-reactive protein, Gastroenterology, Inflammation, Nitric oxide, Tumor necrosis factor alpha, Bioinformatics, Pathology, Biology
- MeSH
- humans, inflammation, magnesium, dietary supplements, middle aged, randomized controlled trials as topic, biomarkers
5 authors
From IT, GB
- Nicola VeroneseUniversity of Palermo
- Damiano Pizzol
- Lee H. SmithAnglia Ruskin University
- Ligia Juliana Dominguez · correspondingUniversità degli Studi di Enna Kore; University of Palermo
- Mario BarbagalloUniversity of Palermo
Abstract
Magnesium (Mg) may have several beneficial effects on human health outcomes. One hypothesized mechanism eliciting such effects is the action of Mg on serum inflammatory parameters. However, studies on this topic to date have several important limitations. Therefore, the present systematic review and meta-analysis aimed to summarize the current state of the art of all randomized control trials (RCTs) investigating the effects of Mg supplementation versus placebo on serum parameters of inflammation. We searched several databases until 23 November 2021 for RCTs. Eligible studies were RCTs investigating the effect of oral Mg supplementation vs. placebo and having serum inflammatory markers as an outcome. Among 2484 papers initially screened, 17 randomized controlled trials (889 participants; mean age: 46 years; females: 62.5%) were included. Generally, a low risk of bias was present. In meta-analysis, Mg supplementation significantly decreased serum C reactive protein (CRP) and increased nitric oxide (NO) levels. In descriptive findings, Mg supplementation significantly reduced plasma fibrinogen, tartrate-resistant acid phosphatase type 5, tumor necrosis factor-ligand superfamily member 13B, ST2 protein, and IL-1. In conclusion, Mg supplementation may significantly reduce different human inflammatory markers, in particular serum CRP and NO levels.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY).
Community trust
Loading…
How much do you trust this study's findings?
Comments
Sign in to rate, comment on or flag this study.Sign inSomething wrong here?
Flag this study if its information, labels or funding look wrong. An editor reviews every flag.
Sign in to rate, comment on or flag this study.Sign inEducational information about published research. Not medical advice, and not a recommendation to start or stop anything.