Funded in part by Dexcom
Continuous Glucose Monitoring in Adolescents With Obesity: Monitoring of Glucose Profiles, Glycemic Excursions, and Adherence to Time Restricted Eating Programs
Naguib MN, Hegedus E, Raymond JK, Goran MI, Salvy SJ, Wee CP, Durazo-Arvizu R, Moss L, Vidmar AP
Frontiers in endocrinology · 29 citations
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- Randomized controlled trial (indexed by PubMed)
- Studied in
- People
- Main outcome
- Health markers and function
Who paid for it
- Funding
- Industry funded
- Nonprofit
- Gustavus and Louise Pfeiffer Research Foundation
- University or hospital
- Children's Hospital Los Angeles
- Government
- National Cancer Research Institute
- University or hospital
- Southern California Clinical and Translational Science Institute
- Company
- Dexcom
- Government
- National Institutes of Health
- University or hospital
- Saban Research Institute
- Government
- National Cancer Institute
- Government
- National Institute of Child Health and Human Development
- Government
- National Center for Research Resources
- Government
- National Center for Advancing Translational Sciences
- Government
- National Institute on Minority Health and Health Disparities
- Government
- Eunice Kennedy Shriver National Institute of Child Health and Human Development
- Government
- NCI NIH HHS
- Government
- NCATS NIH HHS
- Government
- NIMHD NIH HHS
- Government
- NICHD NIH HHS
- Grants
- National Cancer Institute (R01 CA258222); Saban Research Institute (UL1TR001855); National Center for Advancing Translational Sciences (UL1‐TR‐001855); National Institute on Minority Health and Health Disparities (UL1TR001855); Eunice Kennedy Shriver National Institute of Child Health and Human Development (R01 HD092483); National Institute on Minority Health and Health Disparities (U54 MD000502); National Cancer Institute (UL1TR000130); National Institute of Child Health and Human Development (R01HD092483); Children's Hospital Los Angeles (UL1TR000130); Children's Hospital Los Angeles (UL1TR001855); Eunice Kennedy Shriver National Institute of Child Health and Human Development (UL1TR000130); National Center for Advancing Translational Sciences (UL1‐TR‐000130); National Center for Research Resources (UL1 TR000130); National Cancer Institute (UL1TR001855); Eunice Kennedy Shriver National Institute of Child Health and Human Development (UL1TR001855); National Institute on Minority Health and Health Disparities (P50MD017344); National Institutes of Health (UL1TR001855); National Institutes of Health (U54MD000502); National Institutes of Health (UL1 TR000130)
Based on 17 listed funder(s) and full-text disclosure statement.
Publication
- Published
- 2022-02-25 · Front Endocrinol (Lausanne) · vol. 13 · p. 841838
- Publisher
- Frontiers Media
- Cited
- 37 citations · more than 94% of similar papers · 3.4× the field average
- Impact
- Top 10% most cited in its field
- References
- 30 works
- Access
- Open access (journal) · CC-BY
- Research areas
- Dietary Effects on Health · Diabetes Management and Research · Mobile Health and mHealth Applications
- Keywords
- Glycemic, Medicine, Continuous glucose monitoring, Glycemic load, Obesity, Randomized controlled trial, Diabetes mellitus, Meal, Randomization, Clinical trial, Blood Glucose Self-Monitoring, Physical therapy, Glycemic index, Internal medicine, Endocrinology
- MeSH
- humans, diabetes mellitus, glucose, blood glucose, blood glucose self-monitoring, adolescent, adult, female, male, pediatric obesity
9 authors
From US
- Monica N. NaguibChildren's Hospital of Los Angeles
- Elizabeth HegedusChildren's Hospital of Los Angeles
- Jennifer K. RaymondChildren's Hospital of Los Angeles
- Michael I. GoranChildren's Hospital of Los Angeles; Saban Research Institute
- Sarah‐Jeanne SalvyCedars-Sinai Medical Center
- Choo Phei WeeSouthern California Clinical and Translational Science Institute
Abstract
Background
Randomized controlled trials of time restricted eating (TRE) in adults have demonstrated improvements in glucose variability as captured by continuous glucose monitors (CGM). However, little is known about the feasibility of CGM use in TRE interventions in adolescents, or the expected changes in glycemic profiles in response to changes in meal-timing. As part of a pilot trial of TRE in adolescents with obesity, this study aimed to 1) assess the feasibility of CGM use, 2) describe baseline glycemic profiles in adolescents with obesity, without diabetes, and 3) compare the difference between glycemic profiles in groups practicing TRE versus control.
Methods
This study leverages data from a 12-week pilot trial (ClinicalTrials.gov Identifier: NCT03954223) of late TRE in adolescents with obesity compared to a prolonged eating window. Feasibility of CGM use was assessed by monitoring 1) the percent wear time of the CGM and 2) responses to satisfaction questionnaires. A computation of summary measures of all glycemic data prior to randomization was done using EasyGV and R. Repeat measures analysis was conducted to assess the change in glycemic variability over time between groups. Review of CGM tracings during periods of 24-hour dietary recall was utilized to describe glycemic excursions.
Results
Fifty participants were enrolled in the study and 43 had CGM and dietary recall data available (16.4 + 1.3 years, 64% female, 64% Hispanic, 74% public insurance). There was high adherence to daily CGM wear (96.4%) without negative impacts on daily functioning. There was no significant change in the glycemic variability as measured by standard deviation, mean amplitude glycemic excursion, and glucose area under the curve over the study period between groups.
Conclusions
CGM use appears to be a feasible and acceptable tool to monitor glycemic profiles in adolescents with obesity and may be a helpful strategy to confirm TRE dosage by capturing glycemic excursions compared to self-reported meal timing. There was no effect of TRE on glucose profiles in this study. Further research is needed to investigate how TRE impacts glycemic variability in this age group and to explore if timing of eating window effects these findings.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY).
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