Effects of blueberry and cranberry on type 2 diabetes parameters in individuals with or without diabetes: A systematic review and meta-analysis of randomized clinical trials
Delpino FM, Figueiredo LM, Gonçalves da Silva T, Flores TR
Nutrition, metabolism, and cardiovascular diseases : NMCD · 19 citations
How it was studied
- Design
- Meta-analysis (indexed by PubMed)
- Studied in
- People
- Main outcome
- Health markers and function
- Intake measured by
- Not stated
Who paid for it
- Funding
- Independent funding
- Government
- Conselho Nacional de Desenvolvimento Científico e Tecnológico
- Government
- Conselho Nacional de Desenvolvimento Cientifico e Tecnologico
Based on 2 listed funder(s).
Publication
- Published
- 2022-02-16 · Nutr Metab Cardiovasc Dis · vol. 32 · issue 5 · pp. 1093–1109
- Publisher
- Elsevier BV
- Cited
- 26 citations · more than 78% of similar papers · 1.4× the field average
- References
- 64 works
- Access
- Paywalled
- Research areas
- Phytochemicals and Antioxidant Activities · Natural Antidiabetic Agents Studies · Metabolism, Diabetes, and Cancer
- Keywords
- Type 2 diabetes, Meta-analysis, Randomized controlled trial, Medicine, Diabetes mellitus, Internal medicine, Endocrinology
- MeSH
- humans, vaccinium macrocarpon, diabetes mellitus, type 2, insulin resistance, blood glucose, plant extracts, randomized controlled trials as topic, blueberry plants, glycated hemoglobin
4 authors
From BR
- Felipe Mendes Delpino · correspondingUniversidade Federal de Pelotas
- Lílian Munhoz FigueiredoUniversidade Federal de Pelotas
- Taiciane Gonçalves da SilvaUniversidade Federal de Pelotas
- Thaynã Ramos FloresUniversidade Federal de Pelotas
Abstract
Aims
Blueberry and cranberry are rich in polyphenols that are associated with diabetes reduction. This study aimed: 1) to systematically review the literature on the effects of blueberry and cranberry consumption and type 2 diabetes parameters in individuals with or without type 2 diabetes and 2) to quantify these effects by carrying out a meta-analysis.
Data synthesis
A systematic review and meta-analysis were performed using articles present in seven databases (PubMed, LILACS, Scielo, Scopus, Web of Science, Cochrane, and Embase), including publications until May 2021. We included randomized clinical trials that compared blueberry or cranberry effects on type 2 diabetes parameters, such as fasting blood glucose, insulin resistance, and glycated hemoglobin. Quality of the studies was performed using the Cochrane scale, while the Egger test assessed the publication bias and meta-regression the estimated effect sizes with potential moderator variables. From the 2034 studies identified, 39 were read in full and 22 were included in meta-analysis. In individuals with diabetes, the consumption of blueberry or cranberry significantly reduced fasting blood glucose [MD: -17.72 mg/dl; 95% CI: -29.62, -5.82; p = 0.03; I2 = 57%] and glycated hemoglobin [MD: -0.32%; 95% CI: -0.57, -0.07; p = 0.15; I2 = 39%], whereas for insulin resistance the effects were null. Results were not significant for the general population, except in the sensitivity analysis for fasting blood glucose.
Conclusions
The consumption of blueberry and cranberry significantly reduced fasting blood glucose and glycated hemoglobin levels in individuals with diabetes, with high credibility of the evidence.
Abstract via Europe PMC. Copyright remains with the authors or publisher.
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