Association Between Egg Consumption and Dementia Risk in the EPIC-Spain Dementia Cohort
Margara-Escudero HJ, Zamora-Ros R, de Villasante I, Crous-Bou M, Chirlaque MD, Amiano P, Mar J, Barricarte A, Ardanaz E, Huerta JM
Frontiers in nutrition · 14 citations
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- Cohort study (classified by our AI screen)
- Studied in
- People
- Main outcome
- Clinical events such as disease or death
- Intake measured by
- Food frequency questionnaire
Who paid for it
- Funding
- Independent funding
- Government
- Centres de Recerca de Catalunya
- Government
- Generalitat de Catalunya
- Government
- Instituto de Salud Carlos III
- Government
- European Social Fund
- Grants
- Instituto de Salud Carlos III (CPII20/00009)
Based on 4 listed funder(s) and full-text disclosure statement.
Publication
- Published
- 2022-02-23 · Front Nutr · vol. 9 · p. 827307
- Publisher
- Frontiers Media
- Cited
- 18 citations · more than 85% of similar papers · 1.9× the field average
- References
- 38 works
- Access
- Open access (journal) · CC-BY
- Research areas
- Nutritional Studies and Diet · Dementia and Cognitive Impairment Research · Alzheimer's disease research and treatments
- Keywords
- Dementia, Medicine, European Prospective Investigation into Cancer and Nutrition, Hazard ratio, Prospective cohort study, Mediterranean diet, Rotterdam Study, Proportional hazards model, Cohort, Confounding, Cohort study, Population, Lower risk, Demography, Internal medicine, Disease, Environmental health, Confidence interval
10 authors
From ES, US
- Hernando J. Margara‐EscuderoInstitut d'Investigació Biomédica de Bellvitge; Institut Català d'Oncologia
- Raúl Zamora‐Ros · correspondingInstitut d'Investigació Biomédica de Bellvitge; Institut Català d'Oncologia
- Izar VillasanteInstitut d'Investigació Biomédica de Bellvitge; Institut Català d'Oncologia
- Marta Crous‐BouHarvard University; Institut d'Investigació Biomédica de Bellvitge; Institut Català d'Oncologia
- María‐Dolores ChirlaqueInstituto Murciano de Investigación Biosanitaria; Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública
- Pilar AmianoBasque Government; Ministry of Health; Biogipuzkoa Health Research Institute; Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública
Abstract
Background
Current evidence suggests that egg composition might have potential neuroprotective effects. Our aim was to determine the association between egg consumption and the risk of dementia in a Mediterranean population.
Methods
This study was carried out in 3 centers from the European Prospective Investigation into Cancer and Nutrition (EPIC)-Spain Dementia Cohort, i.e., 25,015 participants aged 30-70 years, recruited in 1992-1996, and followed up for a mean of 21.5 years.
Results
A total of 774 incident dementia cases were diagnosed and validated, of which 518 were Alzheimer's disease (AD). Data on egg consumption were estimated using a validated dietary history questionnaire at recruitment. Cox proportional hazards models, adjusted for confounders, were used in the analyses. No association was observed between egg consumption and either total dementia [hazard ratio between extreme quartiles (HRQ4vs.Q1: 1.05; 95% CI 0.85-1.31; p-trend = 0.93)] or AD (HRQ4vs.Q1 0.93; 95% CI 0.72-1.21; p-trend = 0.50) risks. After dividing the population by adherence to the relative Mediterranean diet (rMED) score, a borderline inverse association was found between egg intake and both total dementia (HRQ4vs.Q1: 0.52; 95% CI 0.30-0.90; p-trend = 0.10) and AD (HRQ4vs.Q1: 0.52; 95% CI 0.27-1.01; p-trend = 0.13) risks within participants with low adherence to rMED score. However, no association was observed in participants with medium and high adherence to rMED score.
Conclusion
This prospective study suggests that egg consumption is associated with a reduced risk of dementia, and specifically of AD, in the adult population with low adherence to rMED score; whereas it has no impact in subjects with moderate and high MD adherence.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY).
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