Dietary Magnesium Intake Modifies the Association Between Vitamin D and Systolic Blood Pressure: Results From NHANES 2007-2014
Huang W, Ma X, Chen Y, Zheng J, Li H, Nizhamu A, Hong Q, Guo X
Frontiers in nutrition · 14 citations
How it was studied
- Design
- Cross-sectional study (classified by our AI screen)
- Studied in
- People
- Main outcome
- Health markers and function
Who paid for it
- Funding
- Independent funding
- Government
- Chinese People’s Liberation Army
Based on 1 listed funder(s) and full-text disclosure statement.
Publication
- Published
- 2022-02-24 · Front Nutr · vol. 9 · p. 829857
- Publisher
- Frontiers Media
- Cited
- 15 citations · more than 79% of similar papers · 1.4× the field average
- References
- 38 works
- Access
- Open access (journal) · CC-BY
- Research areas
- Magnesium in Health and Disease · Vitamin D Research Studies · Parathyroid Disorders and Treatments
- Keywords
- National Health and Nutrition Examination Survey, Blood pressure, Medicine, Magnesium, Vitamin D and neurology, Vitamin, Internal medicine, Dietary Reference Intake, Endocrinology, Vitamin C, Nutrient, Chemistry, Population, Environmental health
8 authors
From CN
- Wei-Chao HuangSecond Affiliated Hospital of Guangzhou Medical University; Third Affiliated Hospital of Guangzhou Medical University; Guangzhou Medical University
- Xiaoman MaThird Affiliated Hospital of Guangzhou Medical University; Guangzhou Medical University
- Yue ChenSecond Affiliated Hospital of Guangzhou Medical University; Third Affiliated Hospital of Guangzhou Medical University; Guangzhou Medical University
- Jiayi ZhengSecond Affiliated Hospital of Guangzhou Medical University; Third Affiliated Hospital of Guangzhou Medical University; Guangzhou Medical University
- Haojia LiThird Affiliated Hospital of Guangzhou Medical University; Guangzhou Medical University
- Ayinigaer NizhamuSecond Affiliated Hospital of Guangzhou Medical University; Third Affiliated Hospital of Guangzhou Medical University; Guangzhou Medical University
Abstract
Introduction
Although the association between blood pressure and vitamin D has been well studied, the effects of dietary magnesium intake on this relationship are still unclear. Thus, this study aimed to determine the effects of dietary magnesium intake on the association between vitamin D and blood pressure.
Methods
The present study analyzed data from the continuous the National Health and Nutrition Examination Survey (NHANES) 2007-2014. We included 8,799 participants aged 20 years or older. Multivariable linear regression was performed to assess the association between vitamin D and systolic blood pressure (SBP) and diastolic blood pressure (DBP). Dietary magnesium intake was stratified by low magnesium intake (<299 mg/d) and high magnesium intake (≥299 mg/d). Effect modification by dietary magnesium intake was assessed through interaction tests between vitamin D and SBP in the multivariable linear regression.
Results
In this cross-sectional study, we found that vitamin D was negatively related to SBP, but not to DBP. The relationship between vitamin D and SBP was different in the low and high magnesium intake group (β: -0.25 95%Cl: -0.4~0.07 vs β: -0.32 95%Cl: -0.52~-0.12). Furthermore, magnesium intake significantly modified the negative relationship between vitamin D and SBP in most of the models.
Conclusion
Our research showed that magnesium and vitamin D have an interactive effect in reducing SBP, which may have great importance for clinical medication.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY).
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