5-Heptadecylresorcinol Protects against Atherosclerosis in Apolipoprotein E-Deficient Mice by Modulating SIRT3 Signaling: The Possible Beneficial Effects of Whole Grain Consumption
Hao Y, Yang Z, Li Q, Wang Z, Liu J, Wang J
Molecular nutrition & food research · 8 citations
How it was studied
- Design
- Animal study (classified by our AI screen)
- Studied in
- People, plus animal or lab work
- Main outcome
- Health markers and function
Who paid for it
- Funding
- Independent funding
- Government
- National Natural Science Foundation of China
- Government
- Beijing Municipal Commission of Education
- Grants
- Beijing Municipal Commission of Education (KM202110011004); National Natural Science Foundation of China (32172207)
Based on 2 listed funder(s).
Publication
- Published
- 2022-03-17 · Mol Nutr Food Res · vol. 66 · issue 9 · p. e2101114
- Publisher
- Wiley
- Cited
- 13 citations · more than 78% of similar papers · 1.4× the field average
- References
- 42 works
- Access
- Paywalled
- Research areas
- Food composition and properties · Cardiovascular Disease and Adiposity · Phytochemicals and Antioxidant Activities
- Keywords
- Apolipoprotein E, Triglyceride, Apolipoprotein B, Apoptosis, Internal medicine, Endocrinology, Cholesterol, Western blot, Medicine, Pharmacology, Chemistry, Biochemistry, Disease
- MeSH
- animals, mice, inbred c57bl, mice, knockout, humans, mice, resorcinols, apolipoproteins e, signal transduction, atherosclerosis, sirtuin 3, plaque, atherosclerotic, human umbilical vein endothelial cells, whole grains
6 authors
From CN
- Yiming HaoBeijing Technology and Business University
- Zihui YangBeijing Technology and Business University
- Qing LiBeijing Technology and Business University
- Ziyuan WangBeijing Technology and Business University
- Jie Liu · correspondingBeijing Technology and Business University
- Jing Wang · correspondingBeijing Technology and Business University
Abstract
Scope
Whole grain consumption has been proven to be inversely associated with the risk of cardiovascular diseases. As a biomarker for whole grain dietary intake, 5-heptadecylresorcinol (AR-C17) has attracted increased attention due to its potential health-improving activity. However, the beneficial effect of AR-C17 on atherosclerosis prevention and the underlying mechanism remain unclear.
Methods and results
High-fat diet fed apolipoprotein E-deficient (ApoE-/- ) mice are administrated with or without AR-C17 (30 and 150 mg kg-1 ) for 16 weeks. Histological staining is performed for plaque analysis. Immunofluorescence, western blot, and seahorse cell analysis are carried out to investigate the action of mechanism of AR-C17. The results indicate that AR-C17 supplementation lowered serum total cholesterol, triglyceride, VLDL-C, and LDL-C levels. Moreover, the atherosclerotic plaques in the aortic root region of mice heart are significantly reduced by AR-C17 intervention compared with ApoE-/- control group. In addition, AR-C17 treatment alleviates endothelial cell damage and apoptosis by improving mitochondrial function via sirtuin3 signaling pathway both in ApoE-/- mice and oxidized-LDL-treated human umbilical vein endothelial cells.
Conclusion
AR-C17 may be applied as a promising grain-based dietary bioactive ingredient for atherosclerosis prevention. Meanwhile, as a mitochondrial protective agent, it can offer support for the suggested health claim of whole grain diet.
Abstract via Europe PMC. Copyright remains with the authors or publisher.
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