Bladder volume reproducibility after water consumption in patients with prostate cancer undergoing radiotherapy: A systematic review and meta-analysis
Chen HH, Lin PT, Kuo LT, Lin KS, Fang CC, Chi CC
Biomedical journal · 13 citations
How it was studied
- Design
- Meta-analysis (indexed by PubMed)
- Studied in
- People
- Main outcome
- Health markers and function
Who paid for it
- Funding
- Independent funding
Based on full-text disclosure statement.
Publication
- Published
- 2020-11-05 · Biomed J · vol. 44 · issue 6 · pp. S226–S234
- Publisher
- Elsevier BV
- Cited
- 19 citations · more than 70% of similar papers · 0.6× the field average
- References
- 35 works
- Access
- Open access (journal) · CC-BY-NC-ND
- Research areas
- Advanced Radiotherapy Techniques · Prostate Cancer Diagnosis and Treatment · Radiation Therapy and Dosimetry
- Keywords
- Medicine, Reproducibility, Meta-analysis, Randomized controlled trial, Radiation therapy, Bladder cancer, Prostate cancer, Prostate, Confidence interval, Cancer, Internal medicine
- MeSH
- humans, prostatic neoplasms, water, reproducibility of results, drinking, male, urinary bladder, randomized controlled trials as topic
6 authors
From TW
- Hsiao-Hsuan ChenChiayi Chang Gung Memorial Hospital
- Pei-Tzu LinChiayi Chang Gung Memorial Hospital
- Liang‐Tseng KuoChiayi Chang Gung Memorial Hospital
- Kun-Sheng LinChiayi Chang Gung Memorial Hospital
- Chiung-Chen FangChiayi Chang Gung Memorial Hospital
- Ching‐Chi Chi · correspondingChang Gung University; Chang Gung Memorial Hospital; Linkou Chang Gung Memorial Hospital
Abstract
Background
To minimize toxicity due to radiotherapy in patients with prostate cancer, high bladder volume reproducibility is essential. Water consumption is often used to increase bladder volume reproducibility, but the optimal amount of water required to be consumed remains unclear. We aimed to analyzed the relationship between water consumption and bladder volume reproducibility in patients undergoing radiotherapy for prostate cancer.
Methods
We conducted a systematic review and meta-analysis of randomized controlled trials and cohort studies that assessed bladder volume change after water consumption in patients with prostate cancer undergoing radiotherapy. MEDLINE, Embase, and Cochrane Central Register of Controlled Trials were searched for relevant studies published from database inception up until July 4, 2020. The Newcastle-Ottawa Scale was used to evaluate the risk of bias in the included studies. The outcome was the mean difference (MD) of bladder volume after water consumption, evaluated through meta-analysis using a random-effects model.
Results
Ten cohort studies and one randomized controlled trial with a total of 417 patients were included. For 300-400 ml water consumption, the bladder volume MD between during treatment and at computer tomography-simulation (95% confidence interval [CI]) was -11.97 (-51.68 to 27.74), was -45.99 (-82.85 to -9.13) for 500-540 ml water consumption and -45.92 (-78.86 to -12.98) for water consumption until full-bladder sensation was reached.
Conclusion
Consuming 300-400 ml of water potentially leads to the best bladder volume reproducibility; moreover, the higher the water consumption volume, the lower the bladder volume reproducibility.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY-NC-ND).
Community trust
Loading…
How much do you trust this study's findings?
Comments
Sign in to rate, comment on or flag this study.Sign inSomething wrong here?
Flag this study if its information, labels or funding look wrong. An editor reviews every flag.
Sign in to rate, comment on or flag this study.Sign inEducational information about published research. Not medical advice, and not a recommendation to start or stop anything.