Ultraprocessed food consumption and kidney function decline in a population-based cohort in the Netherlands
Cai Q, Duan MJ, Dekker LH, Carrero JJ, Avesani CM, Bakker SJL, de Borst MH, Navis GJ
The American journal of clinical nutrition · 45 citations
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- Cohort study (indexed by PubMed)
- Studied in
- People
- Main outcome
- Clinical events such as disease or death
- Intake measured by
- Food frequency questionnaire
Who paid for it
- Funding
- Independent funding
- Government
- European Commission
- Government
- Ministerie van Volksgezondheid, Welzijn en Sport
- University or hospital
- Universitair Medisch Centrum Groningen
- University or hospital
- University Medical Center Groningen
- Government
- Marie Skłodowska-Curie
- Government
- Dutch Ministry of Economic Affairs
- Government
- Dutch Ministry of Health, Welfare and Sport
- Government
- European Union
- Grants
- European Commission (HORIZON2020); European Commission (754425)
Based on 8 listed funder(s) and full-text disclosure statement.
Publication
- Published
- 2022-03-25 · Am J Clin Nutr · vol. 116 · issue 1 · pp. 263–273
- Publisher
- Elsevier BV
- Cited
- 59 citations · more than 99% of similar papers · 9.5× the field average
- Impact
- Top 10% most cited in its field
- References
- 68 works
- Access
- Open access (hybrid journal) · CC-BY-NC
- Research areas
- Consumer Attitudes and Food Labeling · Nutrition, Genetics, and Disease · Nutritional Studies and Diet
- Keywords
- Consumption (sociology), Cohort, Food consumption, Population, Environmental health, Demography, Medicine, Economics, Agricultural economics, Internal medicine, Sociology
- MeSH
- kidney, humans, diet, cohort studies, prospective studies, netherlands, renal insufficiency, chronic, fast foods
8 authors
From NL, CN, US, SE
- Qingqing Cai · correspondingUniversity Medical Center Groningen; University of Groningen; Key Laboratory of Guangdong Province; Nanfang Hospital; National Clinical Research; Southern Medical University
- Ming-Jie DuanUniversity Medical Center Groningen; University of Groningen
- Louise H. DekkerUniversity Medical Center Groningen; University of Groningen
- Juan Jesús CarreroKarolinska Institutet
- Carla María AvesaniKarolinska Institutet
- Stephan J. L. BakkerUniversity Medical Center Groningen; University of Groningen
Abstract
Background
Ultraprocessing makes food products more convenient, appealing, and profitable. Recent studies show that high ultraprocessed food (UPF) intake is associated with cardiometabolic diseases.
Objectives
The aim of this study is to investigate the association between UPF consumption and risks of kidney function decline in the general population.
Methods
In a prospective, general population-based Lifelines cohort from Northern Netherlands, 78,346 participants free of chronic kidney disease (CKD) at baseline responded to a 110-item FFQ. We used a multivariable regression analysis to study the associations of the proportion (in grams/day) of UPFs in the total diet with a composite kidney outcome [incident CKD or a ≥30% estimated glomerular filtration rate (eGFR) decline relative to baseline] and annual change in eGFR.
Results
On average, 37.7% of total food intake came from UPFs. After 3.6 ± 0.9 years of follow-up, 2470 participants (3.2%) reached the composite kidney outcome. Participants in the highest quartile of UPF consumption were associated with a higher risk of the composite kidney outcome (OR, 1.27; 95% CI, 1.09-1.47; P = 0.003) compared with those in the lowest quartile, regardless of their macro- or micronutrient intake or diet quality. Participants in the highest quartile had a more rapid eGFR decline (β, -0.17; 95% CI, -0.23 to -0.11; P < 0.001) compared with those in the lowest quartile. Associations were generally consistent across different subgroups.
Conclusions
Higher UPF consumption was associated with a higher risk of a composite kidney outcome (incident CKD or ≥30% eGFR decline) and a more rapid eGFR decline in the general population, independent of confounders and other dietary indices.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY-NC).
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