A single dose of dietary nitrate supplementation protects against endothelial ischemia-reperfusion injury in early postmenopausal women
Somani YB, Soares RN, Gosalia J, Delgado JM, Flanagan M, Basu S, Kim-Shapiro DB, Murias JM, Proctor DN
Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme · 16 citations
How it was studied
- Design
- Randomized controlled trial (indexed by PubMed)
- Studied in
- People
- Main outcome
- Health markers and function
- Intake measured by
- Not stated
Who paid for it
- Funding
- Independent funding
- University or hospital
- University of Pennsylvania
- University or hospital
- Pennsylvania State University
- Government
- National Institutes of Health
- Government
- National Institute on Aging
- Government
- National Heart, Lung, and Blood Institute
- Government
- NHLBI NIH HHS
- University or hospital
- Penn State Hershey Family and Community Medicine
- Government
- NIA NIH HHS
- Grants
- National Institute on Aging (R21 AG054940); National Heart, Lung, and Blood Institute (R01 HL098032); National Institutes of Health (HL098032)
Based on 8 listed funder(s).
Publication
- Published
- 2022-03-31 · Appl Physiol Nutr Metab · vol. 47 · issue 7 · pp. 749–761
- Publisher
- NRC Research Press
- Cited
- 22 citations · more than 90% of similar papers · 2.4× the field average
- References
- 59 works
- Access
- Open access (repository copy)
- Research areas
- Nitric Oxide and Endothelin Effects · Cardiac Ischemia and Reperfusion · Eicosanoids and Hypertension Pharmacology
- Keywords
- Reperfusion injury, Medicine, Ischemia, Postmenopausal women, Nitrate, Internal medicine, Endocrinology, Pharmacology, Biology
- MeSH
- endothelium, vascular, humans, reperfusion injury, nitrates, nitric oxide, cross-over studies, double-blind method, postmenopause, dietary supplements, female
9 authors
From US, BR, CA
- Yasina B. SomaniPennsylvania State University
- Rogério N. SoaresCardiovascular Research Center; University of Missouri
- Jigar GosaliaPennsylvania State University
- Jocelyn M. Delgado SpicuzzaPennsylvania State University
- Michael Patrick FlanaganPennsylvania State University; Penn State Milton S. Hershey Medical Center
- Swati BasuVirginia Tech - Wake Forest University School of Biomedical Engineering & Sciences; Wake Forest University
Abstract
The onset of menopause and accompanying changes to ovarian hormones often precedes endothelial dysfunction in women. In particular, accelerated impairments in macrovascular and microvascular function coincide with the loss of estrogen, as does impaired endothelial responses to ischemia-reperfusion (IR) injury. In healthy, early postmenopausal women (n = 12; 3.9 ± 1.5 years since menopause) we tested the hypothesis that acute dietary nitrate (NO3-) supplementation would improve endothelial function and attenuate the magnitude of endothelial dysfunction following whole-arm IR in comparison with placebo. In this randomized, double-blind, placebo-controlled, crossover study we tested participants before and after NO3--rich (BRnitrate) and NO3--depleted (BRplacebo) beetroot juice (BR) consumption, as well as following IR injury, and 15 min after IR to assess recovery. Analyses with repeated-measures general linear models revealed a condition × time interaction for brachial artery flow-mediated dilation (FMD; P = 0.04), and no interaction effect was found for the near-infrared spectroscopy-derived reperfusion slope (P = 0.86). Follow-up analysis showed a significant decline in FMD following IR injury with BRplacebo in comparison with all other timepoints (all, P nitrate (all, P > 0.05). Our findings demonstrate that a single dose of dietary NO3- minimizes IR-induced macrovascular endothelial dysfunction in healthy, early postmenopausal women, but does not improve resting macrovascular and microvascular function. Trial registration number: NCT03644472. Novelty: In healthy, early postmenopausal women, a single dose of NO3--rich BR can protect against IR-induced endothelial dysfunction. This protection may be due to nitric oxide bioactivity during IR rather than improved endothelial function prior to the IR protocol per se.
Abstract via Europe PMC. Copyright remains with the authors or publisher.
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