Effect of Intermittent Fasting Diet on Glucose and Lipid Metabolism and Insulin Resistance in Patients with Impaired Glucose and Lipid Metabolism: A Systematic Review and Meta-Analysis
Yuan X, Wang J, Yang S, Gao M, Cao L, Li X, Hong D, Tian S, Sun C
International journal of endocrinology · 69 citations
How it was studied
- Design
- Meta-analysis (classified by our AI screen)
- Studied in
- People
- Main outcome
- Health markers and function
Who paid for it
- Funding
- Independent funding
- Government
- People's Government of Jilin Province
- University or hospital
- Jilin University
- Government
- Education Department of Jilin Province
- Government
- Department of Science and Technology of Jilin Province
- University or hospital
- First Hospital of Jilin University
- Grants
- Jilin University (JJKH20201081KJ); Jilin University (JDYYJC010); Department of Science and Technology of Jilin Province (JJKH20190032KJ); Education Department of Jilin Province (20180623006TC); Education Department of Jilin Province (JJKH20201081KJ); Jilin University (JJKH20190032KJ); Jilin University (20180623006TC); Department of Science and Technology of Jilin Province (JDYYZH-1902019); Jilin University (20200404213YY); Department of Science and Technology of Jilin Province (JDYYJC010); Department of Science and Technology of Jilin Province (JJKH20201081KJ); Education Department of Jilin Province (20200404213YY); Jilin University (JDYYZH-1902019); Department of Science and Technology of Jilin Province (20200404213YY); Education Department of Jilin Province (JDYYZH-1902019); Education Department of Jilin Province (JJKH20190032KJ); Education Department of Jilin Province (JDYYJC010); Department of Science and Technology of Jilin Province (20180623006TC)
Based on 5 listed funder(s) and full-text disclosure statement.
Publication
- Published
- 2022-03-24 · Int J Endocrinol · vol. 2022 · pp. 1–9
- Publisher
- Hindawi Publishing Corporation
- Cited
- 104 citations · more than 95% of similar papers · 3.6× the field average
- Impact
- Top 10% most cited in its field
- References
- 41 works
- Access
- Open access (journal) · CC-BY
- Research areas
- Dietary Effects on Health · Diet and metabolism studies · Diet, Metabolism, and Disease
- Keywords
- Medicine, Insulin resistance, Lipid metabolism, Carbohydrate metabolism, Internal medicine, Endocrinology, Metabolism, Lipid profile, Fasting glucose, Insulin, Diabetes mellitus
9 authors
From CN
- Xiaojie YuanJilin University; First Hospital of Jilin University
- Jiping WangJilin University; First Hospital of Jilin University
- Shuo YangJilin University; First Hospital of Jilin University
- Mei GaoJilin University; First Hospital of Jilin University
- Lingxia CaoJilin University; First Hospital of Jilin University
- Xumei LiJilin University; First Hospital of Jilin University
Abstract
The question of whether or not intermittent fasting diets improve the clinical indicators of glycolipid metabolism remains unclear. This study systematically reviewed the relevant clinical trials to evaluate the effects of intermittent fasting diet on glucose and lipid metabolism and insulin sensitivity in patients with metabolic syndrome. To evaluate the effect of intermittent fasting diet intervention on patients with disorders of glucose and lipid metabolism, random-effect or fixed-effect meta-analysis models were used to calculate the average difference before and after intermittent fasting diet intervention and the corresponding 95% confidence intervals (CIs). After intermittent fasting diet intervention, in terms of glucose metabolism, fasting blood glucose reduced by 0.15 mmol/L (95% CI: -0.23; -0.06), glycosylated hemoglobin reduced by 0.08 (95% CIs: -0.25; -0.10), insulin plasma levels reduced by 13.25 uUI (95% CIs: -16.69; -9.82), and HOMA-IR decreased by 0.31 on an average (95% CIs: -0.44; -0.19). In addition, BMI decreased by 0.8 kg/m2 (95% CIs: -1.32; -0.28), body weight reduced by 1.87 kg (95% CIs: -2.67; -1.07), and the waist circumference decreased by 2.08 cm (95% CIs: -3.06; -1.10). Analysis of lipid metabolism showed that intermittent fasting diet intervention effectively reduced the total cholesterol level by 0.32 mmol/L (95% CIs: -0.60; -0.05), low-density lipoprotein level by 0.22 mmol/L (95% CIs: -0.37; -0.07), and triglyceride level by 0.04 mmol/L (95% CIs: -0.15; -0.07). Intermittent fasting diets have certain therapeutic effects on blood glucose and lipids in patients with metabolic syndrome and significantly improve insulin resistance. It may be considered as an auxiliary treatment to prevent the occurrence and development of chronic diseases.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY).
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