Funded in part by Alpro Foundation
Longer-term soy nut consumption improves vascular function and cardiometabolic risk markers in older adults: Results of a randomized, controlled cross-over trial
Tischmann L, Adam TC, Mensink RP, Joris PJ
Clinical nutrition (Edinburgh, Scotland) · 18 citations
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- Randomized controlled trial (indexed by PubMed)
- Studied in
- People
- Main outcome
- Health markers and function
- Intake measured by
- Not stated
Who paid for it
- Funding
- Industry funded
- Government
- Nederlandse Organisatie voor Wetenschappelijk Onderzoek
- Company
- Alpro Foundation
- Government
- Dutch Research Council (NWO)
- Grants
- Nederlandse Organisatie voor Wetenschappelijk Onderzoek (015.010.034)
Based on 3 listed funder(s).
Publication
- Published
- 2022-03-14 · Clin Nutr · vol. 41 · issue 5 · pp. 1052–1058
- Publisher
- Elsevier BV
- Cited
- 24 citations · more than 87% of similar papers · 2.1× the field average
- References
- 58 works
- Access
- Open access (hybrid journal) · CC-BY
- Research areas
- Nuts composition and effects · Phytoestrogen effects and research · Nutritional Studies and Diet
- Keywords
- Medicine, Daidzein, Randomized controlled trial, Isoflavones, Soy protein, Internal medicine, Endocrinology, Genistein
- MeSH
- humans, nuts, cardiovascular diseases, cross-over studies, aged, middle aged, female, male, cholesterol, ldl, cholesterol, hdl
4 authors
From US, NL
- Lea TischmannUniversity Medical Center; Maastricht University
- Tanja C. AdamUniversity Medical Center; Maastricht University
- Ronald P. MensinkUniversity Medical Center; Maastricht University
- Peter J. Joris · correspondingMaastricht University Medical Centre; University Medical Center; Maastricht University
Abstract
Background
Soy foods may contribute to the beneficial health effects of healthy plant-based diets on the risk to develop cardiovascular disease (CVD). However, their effects on vascular function have hardly been studied.
Objective
To investigate longer-term effects of soy nut consumption on vascular function and cardiometabolic risk markers in healthy older men and women.
Design
Twenty-three healthy participants (age: 60-70 years; BMI: 20-30 kg/m2) participated in a randomized, controlled, single-blinded cross-over trial with an intervention (67 g/day of soy nuts providing 25.5 g protein and 174 mg isoflavones) and control period (no nuts) of 16 weeks, separated by eight weeks wash-out. Adults followed the Dutch food-based dietary guidelines.
Results
No serious adverse events were reported and the soy nut regime was well tolerated. Body weights remained stable during the whole study. A higher protein (3.1 energy percent [En%]) and a lower carbohydrate intake (2.0 En%) was observed during the intervention period. Total fat intake was comparable, but that of saturated (-1.3 En%), cis-monounsaturated (-1.5 En%) and cis-polyunsaturated fatty acids (+1.9 En%) differed. Serum isoflavone concentrations were higher after the intervention as compared with the control period (daidzein: 127.8 ng/mL; 95% CI: 74.3-181.3 ng/mL; p < 0.001 and genistein: 454.2 ng/mL; 95% CI: 266.6-641.8 ng/mL; p < 0.001). Brachial artery flow-mediated vasodilation was 1.48 percent points (pp; 95% CI: 0.08-2.89 pp; p = 0.040) higher following soy nut intake. The carotid artery reactivity response and arterial stiffness did not differ. Serum LDL-cholesterol was lower (0.17 mmol/L; 95% CI: 0.02-0.32 mmol/L; p = 0.027), while HDL-cholesterol and triacylglycerol concentrations were comparable. Mean arterial pressure (MAP) was lower (3 mmHg; 95% CI: 0-6 mmHg; p = 0.035).
Conclusions
Longer-term soy nut intake as part of a healthy diet improved endothelial function, LDL-cholesterol concentrations and MAP levels, suggesting mechanisms by which an increased soy food intake beneficially affects CVD risk in older adults. Registered under ClinicalTrials.gov Identifier no. NCT03627637.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY).
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