Evaluation of the Effects of Oral Magnesium Sachet on the Prevention of Spinal Anesthesia-Induced Headache After Cesarean Section: A Randomized Clinical Trial
Nikooseresht M, Hajian P, Moradi A, Sanatkar M
Anesthesiology and pain medicine · 2 citations
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- Randomized controlled trial (classified by our AI screen)
- Studied in
- People
- Main outcome
- Clinical events such as disease or death
Who paid for it
- Funding
- Funding not disclosed
Publication
- Published
- 2022-03-22 · Anesth Pain Med · vol. 12 · issue 1 · p. e121834
- Publisher
- Kowsar Medical (Netherlands)
- Cited
- 3 citations · more than 65% of similar papers · 0.6× the field average
- References
- 39 works
- Access
- Open access (free to publish) · CC-BY-NC
- Research areas
- Anesthesia and Pain Management · Enhanced Recovery After Surgery · Preterm Birth and Chorioamnionitis
- Keywords
- Medicine, Anesthesia, Randomized controlled trial, Spinal anesthesia, Analgesic, Clinical trial, Complication, Magnesium, Pregnancy, Surgery, Internal medicine
4 authors
From IR
- Mahshid NikoosereshtHamedan University of Medical Sciences
- Pouran Hajian · correspondingHamedan University of Medical Sciences
- Abas MoradiHamedan University of Medical Sciences
- Maryam SanatkarHamedan University of Medical Sciences
Abstract
Background
Post-dural puncture headache (PDPH) is a common complication of spinal anesthesia. It often goes away after a few days but may be more severe in some patients and persists for weeks.
Objectives
This study aimed to evaluate the effect of oral magnesium on the prevention of PDPH after cesarean section for the first time.
Methods
In this double-blind, randomized clinical trial, 100 candidates for elective cesarean section under spinal anesthesia were randomly divided into 2 groups: (i) the intervention group that received 300 mg of oral magnesium powder and (ii) the control group that received starch powder. The frequency and severity of headache and amount of analgesic consumption in both groups were measured 1, 2, and 3 days after cesarean section. Data were analyzed using SPSS version 22 at 95% CI.
Results
The frequency of PDPH 1, 2, and 3 days after surgery was 8% vs 24% (P = 0.029), 10% vs 26% (P = 0.039), and 12% vs 18% (P = 0.401) in the intervention and control groups, respectively. The mean and SD of pain severity was 0.52 ± 1.83 vs 1.5 ± 2.84 (P = 0.03) on the first day, 0.70 ± 2.19 vs 1.58 ± 2.86 (P = 0.05) on the second day, and 0.82 ± 2.32 vs 1.18 ± 2.62 on the third day (P = 0.43) in the intervention and control groups, respectively. Although more patients in the control group received rescue analgesia, no significant difference was seen between the 2 study groups.
Conclusions
In women candidates for cesarean section, oral administration of 300 mg magnesium 2 hours before surgery significantly reduces the frequency and severity of PDPH, but its impact on reducing analgesic consumption is not significant.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY-NC).
Community trust
Loading…
How much do you trust this study's findings?
Comments
Sign in to rate, comment on or flag this study.Sign inSomething wrong here?
Flag this study if its information, labels or funding look wrong. An editor reviews every flag.
Sign in to rate, comment on or flag this study.Sign inEducational information about published research. Not medical advice, and not a recommendation to start or stop anything.