Blueberry Supplementation in Midlife for Dementia Risk Reduction
Krikorian R, Skelton MR, Summer SS, Shidler MD, Sullivan PG
Nutrients · 51 citations
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- Randomized controlled trial (indexed by PubMed)
- Studied in
- People
- Main outcome
- Health markers and function
- Intake measured by
- Not stated
Who paid for it
- Funding
- Industry funded
- Government
- National Institute of Neurological Disorders and Stroke
- Government
- NINDS NIH HHS
- Grants
- National Institute of Neurological Disorders and Stroke (R21 NS111217)
Based on 2 listed funder(s) and full-text disclosure statement.
Publication
- Published
- 2022-04-13 · Nutrients · vol. 14 · issue 8 · p. 1619
- Publisher
- Multidisciplinary Digital Publishing Institute
- Cited
- 69 citations · more than 95% of similar papers · 4.2× the field average
- Impact
- Top 10% most cited in its field
- References
- 99 works
- Access
- Open access (journal) · CC-BY
- Research areas
- Neurological Disease Mechanisms and Treatments · Phytochemicals and Antioxidant Activities · Ginkgo biloba and Cashew Applications
- Keywords
- Cognitive decline, Dementia, Cognition, Medicine, Effects of sleep deprivation on cognitive performance, Overweight, Randomized controlled trial, Gerontology, Physiology, Internal medicine, Obesity, Psychiatry
- MeSH
- humans, dementia, risk reduction behavior, cognition, dietary supplements, middle aged, female, male, blueberry plants, cognitive dysfunction
5 authors
From US, AU
- Robert Krikorian · correspondingUniversity of Cincinnati Medical Center
- Matthew R. SkeltonCincinnati Children's Hospital Medical Center; Hospital Research Foundation
- Suzanne S. SummerCincinnati Children's Hospital Medical Center
- Marcelle D. ShidlerUniversity of Cincinnati Medical Center
- Patrick G. SullivanUniversity of Kentucky
Abstract
Late-life dementia typically develops over a period of many years beginning in midlife. Prevalence of metabolic disturbance also accelerates in middle age and is a prominent risk factor for dementia. Preliminary studies indicate that blueberry supplementation can improve cognitive performance and influence metabolism and brain function and therefore may have a role in early intervention to prevent neurodegeneration. In a randomized controlled trial, we investigated the effects of daily blueberry supplementation in a middle-aged sample of insulin-resistant participants with elevated risk for future dementia. We enrolled overweight men and women, aged 50 to 65 years, with subjective cognitive decline (SCD) and performed pre- and post-intervention assessments of cognition and metabolism and exploratory measures of peripheral mitochondrial function. We observed improved performances for the blueberry group on measures of lexical access, p = 0.003, and memory interference, p = 0.04, and blueberry-treated participants reported reduced memory encoding difficulty in daily life activities, p = 0.03. The blueberry-treated group also exhibited correction of peripheral hyperinsulinemia, p = 0.04, and a modest trend for increased mitochondrial uncoupling, p = 0.11. The cognitive findings indicated improved executive ability in this middle-aged sample. In addition, the changes in metabolic and bioenergetic measures imply potential mechanistic factors associated with anthocyanin and proanthocyanidin actions. The demonstration of these benefits in middle-aged individuals with insulin resistance and SCD suggests that ongoing blueberry supplementation may contribute to protection against cognitive decline when implemented early in at-risk individuals.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY).
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