Interactions between red and processed meat consumption and APOA5 gene variants associated with the incidence of metabolic syndrome in Korean adults
Choi WJ, Shin D
Genes & nutrition · 4 citations
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- Cohort study (classified by our AI screen)
- Studied in
- People
- Main outcome
- Clinical events such as disease or death
- Intake measured by
- Food frequency questionnaire
Who paid for it
- Funding
- Independent funding
- Government
- National Research Foundation
- Government
- National Research Foundation of Korea
- Government
- Ministry of Science and ICT, South Korea
- Government
- Centers for Disease Control and Prevention
- Grants
- National Research Foundation of Korea (2020R1G1A1004940)
Based on 4 listed funder(s) and full-text disclosure statement.
Publication
- Published
- 2022-04-25 · Genes Nutr · vol. 17 · issue 1 · p. 5
- Publisher
- BioMed Central
- Cited
- 8 citations · more than 81% of similar papers · 1.6× the field average
- References
- 39 works
- Access
- Open access (journal) · CC-BY
- Research areas
- Nutritional Studies and Diet · Regulation of Appetite and Obesity · Genetic Associations and Epidemiology
- Keywords
- Red meat, Medicine, Metabolic syndrome, Obesity, Incidence (geometry), Diabetes mellitus, Genome-wide association study, Cohort, Minor allele frequency, Clinical nutrition, Internal medicine, Allele, Allele frequency, Genetics, Biology, Single-nucleotide polymorphism, Endocrinology, Gene, Genotype, Pathology
2 authors
From KR
- Woo Jeong ChoiInha University
- Dayeon Shin · correspondingInha University
Abstract
Background
Metabolic syndrome (MetS) is characterized by the coexistence of disorders such as diabetes, hypertension, hyperlipidemia, and obesity and is affected by genetic factors. Previous genome-wide association studies (GWAS) suggested that APOA5 gene variants were significantly associated with MetS and its components. Dietary factors such as red and processed meat consumption can cause chronic diseases, including hypertension, diabetes, and vascular depression. The aim of this study was to investigate the modulation of the incidence of MetS by the interaction between APOA5 rs662799 polymorphism and red and processed meat consumption.
Methods
In this prospective cohort study, 3266 participants were collected from the Korea Association REsource (KARE) cohort of the Korean Genome and Epidemiology Study (KoGES) from 2001 to 2016. APOA5 rs662799 polymorphism was extracted by GWAS using the Korean Chip. Red and processed meat consumption data were assessed using a semi-quantitative food frequency questionnaire.
Results
The incidence of MetS in carriers of the minor G allele of rs662799 (AG + GG) and the third tertile of red and processed meat consumption (serving/day) was higher than those with the major allele of rs662799 (AA) and the first tertile of red and processed meat consumption (HR 1.70, 95% CI 1.30-2.22, p interaction = 0.002).
Conclusions
An association between the presence of the minor alleles of rs662799 and high red and processed meat consumption and the incidence of MetS was observed in Korean adults.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY).
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