Immunomodulatory Effect of SINA 1.2 Therapy Protocol in Asthmatic Mice Model: A Combination of Oxymel and Sauna
Faryabi R, Vaghasloo MA, Athari SS, Boskabady MH, Zangii BM, Kaveh S, Kabiri M
Iranian journal of allergy, asthma, and immunology · 2 citations
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- Animal study (classified by our AI screen)
- Studied in
- Animals
- Main outcome
- Mechanisms only
Who paid for it
- Funding
- Funding not disclosed
Publication
- Published
- 2022-04-17 · Iran J Allergy Asthma Immunol · vol. 21 · issue 2 · pp. 128–140
- Publisher
- Knowledge E
- Cited
- 3 citations · more than 53% of similar papers · 0.3× the field average
- References
- 0 works
- Access
- Open access (journal) · CC-BY-NC
- Research areas
- Asthma and respiratory diseases · Herbal Medicine Research Studies · Immune Cell Function and Interaction
- Keywords
- Medicine, Budesonide, Ovalbumin, Asthma, Inflammation, Mucus, Saline, Immunology, Enteral administration, Immune system, Internal medicine, Gastroenterology
- MeSH
- animals, mice, inbred balb c, humans, mice, asthma, inflammation, budesonide, ovalbumin, interleukin-4, interleukin-5, steam bath, male
7 authors
From IR
- Roghaye FaryabiIran University of Medical Sciences; Tehran University of Medical Sciences
- Mahdi Alizadeh VaghaslooIran University of Medical Sciences; Tehran University of Medical Sciences
- Seyyed Shamsadin AthariZanjan University of Medical Sciences
- Mohammad Hossein BoskabadyMashhad University of Medical Sciences
- Bagher Minaii ZangiiTehran University of Medical Sciences
- Shahpar KavehShahid Beheshti University of Medical Sciences
Abstract
Alternative medicine, has become popular in asthmatic patients. We evaluated the immunomodulatory effects of SINA 1.2 therapy protocol derived from Persian medicine in an asthmatic mice model. Forty-two male BALB/c mice divided into six groups: one control (sham) and five sensitized groups (by parenteral injection of 20 μg ovalbumin in 100 μL normal saline plus 50 μL alum on days 1 and 14). Sensitized groups were as: untreated, budesonide (1 mg nebulized budesonide: 200 μg/puff every 5 min for 25 min), dry sauna (30 min, 37°C), oral oxymel (gavaged: 0.2 mL of the syrup plus 0.8 mL of water), and SINA protocol No.1.2 (oxymel followed by sauna) groups. Treatments were given for 10 days from day 23 to 33 then sacrificed. Significant gene expression reduction of interleukin(IL)-4, IL-5, and MUC5AC and increase of interferon(IFN)-γ and IFN-γ/IL-4 ratio and decreased perivascular and peribronchial inflammation, goblet cell hyperplasia, and subsequent mucus hypersecretion in SINA group were seen compared to untreated group. SINA lowered IL-5 and MUC5AC gene expression levels similar to the budesonide and acted better than budesonide in increasing IFN-γ gene expression up to normal level. Compared with the asthma group, sauna alone only affected MUC5AC and IFN-γ gene expressions and oxymel alone, only reduced IL-4 gene expression, perivascular and peribronchial inflammation, and mucus hypersecretion. It seems that SINA therapy alleviates asthma via immune modulation of pro-inflammatory cytokines and improvement of pathological changes in ovalbumin-induced asthma in mice, supporting the notion of innate healing power mentioned in Persian medicine literature.
Abstract via Europe PMC. Copyright remains with the authors or publisher.
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