Associations of the consumption of unprocessed red meat and processed meat with the incidence of cardiovascular disease and mortality, and the dose-response relationship: A systematic review and meta-analysis of cohort studies
de Medeiros GCBS, Mesquita GXB, Lima SCVC, Silva DFO, de Azevedo KPM, Pimenta IDSF, de Oliveira AKDSG, Lyra CO, Martínez DG, Piuvezam G
Critical reviews in food science and nutrition · 27 citations
How it was studied
- Design
- Meta-analysis (indexed by PubMed)
- Studied in
- People
- Main outcome
- Clinical events such as disease or death
- Intake measured by
- Not stated
Who paid for it
- Funding
- Independent funding
- Government
- Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
- Government
- Coordenação de Aperfeiçoamento de Pessoal de Nível Superior – Brasil
- Grants
- Coordenação de Aperfeiçoamento de Pessoal de Nível Superior ((Code 001))
Based on 2 listed funder(s).
Publication
- Published
- 2022-05-01 · Crit Rev Food Sci Nutr · vol. 63 · issue 27 · pp. 8443–8456
- Publisher
- Taylor & Francis
- Cited
- 45 citations · more than 88% of similar papers · 2.3× the field average
- References
- 45 works
- Access
- Open access (repository copy) · OTHER-OA
- Research areas
- Nutritional Studies and Diet · Meat and Animal Product Quality · Agriculture Sustainability and Environmental Impact
- Keywords
- Incidence (geometry), Processed meat, Meta-analysis, Disease, Red meat, Cohort, Medicine, Cohort study, Consumption (sociology), Environmental health, White meat, Food science, Internal medicine, Biology, Pathology
- MeSH
- humans, cardiovascular diseases, coronary disease, diet, incidence, risk factors, prospective studies, meat, meat products, female, stroke, red meat, ischemic stroke
10 authors
From BR, ES
- Gidyenne Christine Bandeira Silva de Medeiros · correspondingConselho Nacional de Desenvolvimento Científico e Tecnológico; Universidade Federal do Rio Grande do Norte
- Gabriella Xavier Barbalho MesquitaUniversidade Federal do Rio Grande do Norte
- Severina Carla Vieira Cunha LimaUniversidade Federal do Rio Grande do Norte
- David Franciole Oliveira SilvaUniversidade Federal do Rio Grande do Norte
- Kesley Pablo Morais de AzevedoConselho Nacional de Desenvolvimento Científico e Tecnológico; Universidade Federal do Rio Grande do Norte
- Isac Davidson Santiago Fernandes PimentaConselho Nacional de Desenvolvimento Científico e Tecnológico; Universidade Federal do Rio Grande do Norte
Abstract
Objectives
The aim of this study was to examine the associations of unprocessed red meat and processed meat consumption with cardiovascular disease (CVD) incidence and mortality, and the dose-response relationship.
Methods
Published literature was retrieved through a structured search of 10 electronic databases: MEDLINE/PubMed, Scopus, SciELO, LILACS, ScienceDirect, Web of Science, Cochrane (CENTRAL), WHOLIS, PAHO and Embase, without language or year of publication restrictions. In addition, we searched the references of published studies. This systematic review was performed in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyzes: The PRISMA Statement.
Results
Twenty-one prospective cohort studies were included in the systematic review. The CVDs evaluated in the inserted studies were stroke, heart failure (HF) and coronary heart disease (CHD). Considering the heterogeneity found in the studies, for the meta-analysis, 9 articles were included. The results presented in the meta-analysis of the association of consumption of unprocessed red meat and CVD indicated that there was a significant association with total stroke incidence (RR 1.10; 95%; CI 1.01 to 1.19; p = 0.02). There was no association with Ischemic stroke incidence, nor CHD Mortality with consumption of unprocessed red meat. However, for Hemorrhagic Stroke Mortality the assessment in the consumption of unprocessed red meat showed an association of protection for women (RR 0.64; 95%; CI 0.45 to 0.91; p = 0.01). As for the results of the meta-analysis of the association between consumption of processed meat and CVD, they indicated that there was a significant association with total stroke incidence (RR 1.17; 95%; CI 1.08 to 1.26; p < 0.0001). There was no association with Ischemic stroke, nor with CHD Mortality with consumption of processed meat. Some studies that showed no association of risk, presented a significant linear trend dose response for the association of the consumption of unprocessed red meat (Bernstein et al. 2010; Nagao et al. 2012) or processed meat (Bernstein et al. 2012) and CVD.
Conclusion
According to the results found in the meta-analysis, the consumption of unprocessed red meat and processed meat are associated with the incidence of stroke, however, no positive association was observed in relation to mortality from CVD. This systematic review and meta-analysis protocol was registered on the PROSPERO (number: CRD42019100914).
Abstract via Europe PMC. Copyright remains with the authors or publisher.
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