Funded in part by Grain Foods Foundation
A randomized controlled trial of the effects of whole grains versus refined grains diets on the microbiome in pregnancy
Sun H, Yamada P, Paetow A, Chan M, Arslan A, Landberg R, Dominguez-Bello MG, Young BK
Scientific reports · 9 citations
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- Randomized controlled trial (indexed by PubMed)
- Studied in
- People
- Main outcome
- Health markers and function
- Intake measured by
- Food frequency questionnaire
Who paid for it
- Funding
- Industry funded
- Industry group
- Grain Foods Foundation
Based on 1 listed funder(s).
Publication
- Published
- 2022-05-07 · Sci Rep · vol. 12 · issue 1 · p. 7509
- Publisher
- Nature Portfolio
- Cited
- 10 citations · more than 65% of similar papers · 0.7× the field average
- References
- 50 works
- Access
- Open access (journal) · CC-BY
- Research areas
- Gut microbiota and health · Pelvic floor disorders treatments · Birth, Development, and Health
- Keywords
- Microbiome, Pregnancy, Gestation, Medicine, Lactobacillus, Obstetrics, Physiology, Obesity, Offspring, Gestational age, Biology, Animal science, Food science, Internal medicine, Bioinformatics
- MeSH
- humans, dietary carbohydrates, diet, pregnancy, infant, newborn, female, male, microbiota, whole grains, gestational weight gain
8 authors
From US, SE
- Haipeng SunRutgers, The State University of New Jersey
- Pamella YamadaNYU Langone Health
- Alexandra PaetowNYU Langone Health
- Michael C. W. ChanNYU Langone Health
- Alan A. ArslanNYU Langone Health
- Rikard LandbergChalmers University of Technology
Abstract
Dietary whole grain consumption has been postulated to have metabolic benefits. The purpose of this study was to compare a pregnancy diet containing 75% of total carbohydrates as refined grains with a diet of 75% of total carbohydrates as whole grains for pregnancy outcomes and effects on the microbiome. Gestational weight gain, glucose tolerance and newborn outcomes were measured on 248 enrolled compliant women from whom a subset of 103 women consented to give 108 vaginal and 109 anal swabs. The data presented here are limited to the patients from whom the vaginal and anal swabs were obtained in order to study the microbiome. A microbiome-16SrRNA survey-was characterized in these samples. Samples and measurements were obtained at the first obstetrical visit, before beginning a prescribed diet (T1-baseline) and after 17-32 weeks on the prescribed diet (T3). Food frequency questionnaires and total plasma alkylresorcinols were used as a measure of whole grain consumption. There were no dietary differences in maternal weight gain, birth weight, or glucose tolerance test. Mothers consuming the whole grains diet showed a trend of gestational decrease in vaginal bacterial alpha diversity, with increasing Lactobacillus-dominance. No significant difference was observed for the anal microbiome. The results suggest that diet modulations of the vaginal microbiome during gestation may have important implications for maternal and neonatal health and in the intergenerational transfer of maternal microbiome. Trial registration: ClinicalTrials.gov Identifier: NCT03232762.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY).
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