Association of egg consumption, metabolic markers, and risk of cardiovascular diseases: A nested case-control study
Pan L, Chen L, Lv J, Pang Y, Guo Y, Pei P, Du H, Yang L, Millwood IY, Walters RG, Chen Y, Gong W, Chen J, Yu C, Chen Z, Li L, China Kadoorie Biobank Collaborative Group
eLife · 10 citations
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- Case-control study (indexed by PubMed)
- Studied in
- People
- Main outcome
- Clinical events such as disease or death
- Intake measured by
- Food frequency questionnaire
Who paid for it
- Funding
- Independent funding
- Nonprofit
- Wellcome Trust
- Nonprofit
- Cancer Research UK
- Government
- National Natural Science Foundation of China
- Government
- Ministry of Science and Technology of the People's Republic of China
- Government
- Medical Research Council
- Government
- National Key Research and Development Program of China
- Government
- Chinese Ministry of Science and Technology
- Nonprofit
- The Kadoorie Charitable Foundation in Hong Kong
- Grants
- National Natural Science Foundation of China (81390544); Wellcome Trust (212946/Z/18/Z); Ministry of Science and Technology of the People's Republic of China (2011BAI09B01); National Natural Science Foundation of China ((91843302); National Natural Science Foundation of China (91846303); Medical Research Council (MC_UU_00017/1); National Key Research and Development Program of China (2016YFC0900500); National Natural Science Foundation of China (81390541); National Natural Science Foundation of China (81390540); National Key Research and Development Program of China (2016YFC0900501); National Natural Science Foundation of China (81941018); Cancer Research UK (29186); National Natural Science Foundation of China (81973125); National Key Research and Development Program of China (2016 YFC0900504)
Based on 8 listed funder(s) and full-text disclosure statement.
Publication
- Published
- 2022-05-03 · Elife · vol. 11
- Publisher
- eLife Sciences Publications Ltd
- Cited
- 9 citations · more than 82% of similar papers · 1.6× the field average
- References
- 36 works
- Access
- Open access (journal) · CC-BY
- Research areas
- Nutritional Studies and Diet · Phytoestrogen effects and research · Nutrition, Genetics, and Disease
- Keywords
- Nested case-control study, Association (psychology), Biology, Genetics, Genetic association, Case-control study, Medicine, Bioinformatics, Internal medicine, Single-nucleotide polymorphism, Gene, Genotype, Psychology
- MeSH
- humans, cardiovascular diseases, cholesterol, apolipoprotein a-i, risk factors, case-control studies, china, biomarkers
17 authors
From CN, GB
- Lang PanPeking University
- Lu ChenPeking University
- Jun LvPeking University
- Yuanjie PangPeking University
- Yu GuoChinese Academy of Medical Sciences & Peking Union Medical College
- Pei PeiAcademy of Medical Sciences; Chinese Academy of Medical Sciences & Peking Union Medical College
Abstract
Background
Few studies have assessed the role of individual plasma cholesterol levels in the association between egg consumption and the risk of cardiovascular diseases. This research aims to simultaneously explore the associations of self-reported egg consumption with plasma metabolic markers and these markers with the risk of cardiovascular disease (CVD).
Methods
Totally 4778 participants (3401 CVD cases subdivided into subtypes and 1377 controls) aged 30-79 were selected based on the China Kadoorie Biobank. Targeted nuclear magnetic resonance was used to quantify 225 metabolites in baseline plasma samples. Linear regression was conducted to assess associations between self-reported egg consumption and metabolic markers, which were further compared with associations between metabolic markers and CVD risk.
Results
Egg consumption was associated with 24 out of 225 markers, including positive associations for apolipoprotein A1, acetate, mean HDL diameter, and lipid profiles of very large and large HDL, and inverse associations for total cholesterol and cholesterol esters in small VLDL. Among these 24 markers, 14 were associated with CVD risk. In general, the associations of egg consumption with metabolic markers and of these markers with CVD risk showed opposite patterns.
Conclusions
In the Chinese population, egg consumption is associated with several metabolic markers, which may partially explain the protective effect of moderate egg consumption on CVD.
Funding
This work was supported by the National Natural Science Foundation of China (81973125, 81941018, 91846303, 91843302). The CKB baseline survey and the first re-survey were supported by a grant from the Kadoorie Charitable Foundation in Hong Kong. The long-term follow-up is supported by grants (2016YFC0900500, 2016YFC0900501, 2016YFC0900504, 2016YFC1303904) from the National Key R&D Program of China, National Natural Science Foundation of China (81390540, 81390541, 81390544), and Chinese Ministry of Science and Technology (2011BAI09B01). The funders had no role in the study design, data collection, data analysis and interpretation, writing of the report, or the decision to submit the article for publication.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY).
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