Relationship between Dietary Magnesium Intake and Metabolic Syndrome
Jiao Y, Li W, Wang L, Jiang H, Wang S, Jia X, Wang Z, Wang H, Zhang B, Ding G
Nutrients · 26 citations
How it was studied
- Design
- Cohort study (classified by our AI screen)
- Studied in
- People
- Main outcome
- Clinical events such as disease or death
Who paid for it
- Funding
- Independent funding
- Government
- Chinese Center for Disease Control and Prevention
- Government
- National Institute for Nutrition and Health
- University or hospital
- University of North Carolina at Chapel Hill
- Government
- National Institute of Diabetes and Digestive and Kidney Diseases
- Government
- Eunice Kennedy Shriver National Institute of Child Health and Human Development
- University or hospital
- Carolina Population Center, University of North Carolina at Chapel Hill
- Government
- NICHD NIH HHS
- Government
- National financial project
- Government
- International Cooperation Project [China Health and Nutrition Survey
- Government
- National Key R&D Program of Ministry of Science and Technology [Research project on dietary nutrition Assessment and intervention techniques
- Government
- NIDDK NIH HHS
- Grants
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (R24 HD-050924); Eunice Kennedy Shriver National Institute of Child Health and Human Development (R01HD030880); National Institute for Nutrition and Health (DK056350); Carolina Population Center, University of North Carolina at Chapel Hill (R01-HD38700); University of North Carolina at Chapel Hill (R24 HD050924); National Institute for Nutrition and Health (R24 HD050924); Eunice Kennedy Shriver National Institute of Child Health and Human Development (R01 HD038700); University of North Carolina at Chapel Hill (R01-HD38700); Carolina Population Center, University of North Carolina at Chapel Hill (R24HD050924); Carolina Population Center, University of North Carolina at Chapel Hill (HD050924); National Institute of Diabetes and Digestive and Kidney Diseases (P30DK-056350); Carolina Population Center, University of North Carolina at Chapel Hill (DK056350); Carolina Population Center, University of North Carolina at Chapel Hill (2020YFC2006300); Chinese Center for Disease Control and Prevention (R01-HD38700); Chinese Center for Disease Control and Prevention (DK056350); University of North Carolina at Chapel Hill (R01-HD30880); National Institute for Nutrition and Health (R01-HD30880); Carolina Population Center, University of North Carolina at Chapel Hill (R01-HD30880); Chinese Center for Disease Control and Prevention (R24 HD050924); Chinese Center for Disease Control and Prevention (R01-HD30880); University of North Carolina at Chapel Hill (DK056350)
Based on 11 listed funder(s) and full-text disclosure statement.
Publication
- Published
- 2022-05-11 · Nutrients · vol. 14 · issue 10 · p. 2013
- Publisher
- Multidisciplinary Digital Publishing Institute
- Cited
- 32 citations · more than 91% of similar papers · 2.7× the field average
- Impact
- Top 10% most cited in its field
- References
- 34 works
- Access
- Open access (journal) · CC-BY
- Research areas
- Magnesium in Health and Disease · Therapeutic Uses of Natural Elements
- Keywords
- Magnesium, Metabolic syndrome, Food science, Medicine, Biology, Chemistry, Endocrinology, Obesity
- MeSH
- humans, obesity, magnesium, diet, incidence, adult, metabolic syndrome
10 authors
From CN
- Yingying JiaoChinese Center For Disease Control and Prevention; National Institute for Nutrition and Health
- Weiyi LiChinese Center For Disease Control and Prevention; National Health and Family Planning Commission; National Institute for Nutrition and Health
- Liusen WangChinese Center For Disease Control and Prevention; National Health and Family Planning Commission; National Institute for Nutrition and Health
- Hongru JiangChinese Center For Disease Control and Prevention; National Health and Family Planning Commission; National Institute for Nutrition and Health
- Shaoshunzi WangChinese Center For Disease Control and Prevention; National Health and Family Planning Commission; National Institute for Nutrition and Health
- Xiaofang JiaChinese Center For Disease Control and Prevention; National Health and Family Planning Commission; National Institute for Nutrition and Health
Abstract
Metabolic syndrome (MetS) is increasingly prevalent, and the relationship between dietary magnesium and MetS remains controversial. Therefore, we aimed to explore the association and dose-response relationship between dietary magnesium intake and MetS and its single component. The sample was adults aged 18 years and above who participated in at least two follow-up surveys in 2009, 2015 and 2018. Food consumption data were collected from three consecutive 24-h dietary recalls. The multivariate Cox proportional risk regression model and restricted cubic spline (RCS) model were used to analyze the association and dose-response relationship between dietary magnesium intake and MetS and its components. In our study, 6104 subjects were included, with a total follow-up of 37,173.36 person-years, and the incidence was 33.16%. Cox regression analysis showed that the multivariable-adjusted Hazard Ratio (HR) for MetS comparing the highest to the lowest quintile of dietary magnesium intake was 0.84 (95% confidence intervals [CI] = 0.71-0.99). Central obesity, elevated TG, elevated blood pressure and elevated blood glucose were reduced by 18%, 41%, 20% and 42%, respectively. The risk of decreased HDL-C was reduced by 23% in the third quintile of dietary magnesium intake, with a slightly increased risk in the highest group. RCS analysis showed that the overall and non-linear associations between dietary magnesium and MetS and its components were statistically significant, the risk of them decreased significantly when magnesium intake was lower than 280 mg/day, and then the curve leveled off or slightly increased.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY).
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