Association of Dietary Magnesium Intake With Leukocyte Telomere Length in United States Middle-Aged and Elderly Adults
Hu L, Bai Y, Hu G, Zhang Y, Han X, Li J
Frontiers in nutrition · 8 citations
How it was studied
- Design
- Cross-sectional study (classified by our AI screen)
- Studied in
- People
- Main outcome
- Health markers and function
Who paid for it
- Funding
- Independent funding
- Government
- National Natural Science Foundation of China
- University or hospital
- Beihang University
- University or hospital
- Peking University
- Government
- National Key Research and Development Program of China
- Grants
- National Natural Science Foundation of China (82003427); National Key Research and Development Program of China (2021YFC2500600); Beihang University (YWF-20-BJ-J-1053); National Natural Science Foundation of China (2021YFC2500600); National Key Research and Development Program of China (2021YFC2500601)
Based on 4 listed funder(s) and full-text disclosure statement.
Publication
- Published
- 2022-05-19 · Front Nutr · vol. 9 · p. 840804
- Publisher
- Frontiers Media
- Cited
- 9 citations · more than 74% of similar papers · 1.0× the field average
- References
- 45 works
- Access
- Open access (journal) · CC-BY
- Research areas
- Telomeres, Telomerase, and Senescence · Magnesium in Health and Disease · Genetics, Aging, and Longevity in Model Organisms
- Keywords
- Confounding, Medicine, National Health and Nutrition Examination Survey, Magnesium, Confidence interval, Telomere, Demography, Physiology, Internal medicine, Animal science, Environmental health, Biology, Population, Chemistry
6 authors
From CN
- Lihua HuPeking University; Peking University First Hospital
- Yi BaiPeking University
- Guiping Hu · correspondingBeijing Advanced Sciences and Innovation Center; Beihang University
- Yan ZhangPeking University; Peking University First Hospital
- Xiaoning HanPeking University; Peking University First Hospital
- Jianping Li · correspondingPeking University; Peking University First Hospital
Abstract
Aim
Magnesium supplementation may extend the life span; however, the biological mechanism is still unknown. Leukocyte telomere length (LTL) is a marker of cell aging and biological health in humans. Data concerning whether magnesium supplementation can maintain telomere length, thus prolonging life are limited. We aimed to investigate the association between dietary magnesium intake and LTL in United States middle-aged and elderly adults.
Methods
A total of 4,039 United States adults aged ≥ 45 years from National Health and Nutrition Examination Survey (1999-2002). Dietary magnesium intake was collected by a trained interviewer using 24-h dietary recall method and LTL was obtained using the quantitative polymerase chain reaction method. Multiple linear regression analysis was performed to evaluate the crude and adjusted association of dietary magnesium intake with LTL.
Results
The overall mean (SD) of LTL was 5.6 (0.6) kp. After adjusting potential confounders, every 1 mg increase in log-transformed dietary magnesium intake was associated with 0.20 kp (95% confidence intervals: 0.05-0.34) longer LTL. Participants with the highest tertile (≥299 mg) of dietary magnesium intake had statistically significant longer LTL (β = 0.07, P = 0.038) compared with the lowest tertile (P for interaction = 0.002). E-value analysis suggested robustness to unmeasured confounding.
Conclusion
Our findings showed that increased dietary magnesium intake was associated with longer LTL, which suggested that magnesium was conducive to a longer life expectancy.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY).
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