Plasma Amino Acid Appearance and Status of Appetite Following a Single Meal of Red Meat or a Plant-Based Meat Analog: A Randomized Crossover Clinical Trial
Pham T, Knowles S, Bermingham E, Brown J, Hannaford R, Cameron-Smith D, Braakhuis A
Current developments in nutrition · 31 citations
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- Randomized controlled trial (classified by our AI screen)
- Studied in
- People
- Main outcome
- Health markers and function
- Intake measured by
- Food provided by researchers
Who paid for it
- Funding
- Independent funding
Based on full-text disclosure statement.
Publication
- Published
- 2022-04-28 · Curr Dev Nutr · vol. 6 · issue 5 · p. nzac082
- Publisher
- Elsevier BV
- Cited
- 47 citations · more than 98% of similar papers · 6.7× the field average
- Impact
- Top 10% most cited in its field
- References
- 62 works
- Access
- Open access (journal) · CC-BY-NC-ND
- Research areas
- Agriculture Sustainability and Environmental Impact · Meat and Animal Product Quality · Nutritional Studies and Diet
- Keywords
- Postprandial, Crossover study, Meal, Appetite, Food science, Amino acid, Pasture, Animal science, Biology, Chemistry, Medicine, Biotechnology, Biochemistry, Insulin, Internal medicine, Agronomy
7 authors
From NZ, AU
- Toan Thanh Pham · correspondingUniversity of Auckland
- Scott O. KnowlesAgResearch
- Emma N. BerminghamAgResearch
- Julie. E. BrownUniversity of Auckland
- Rina HannafordAgResearch
- David Cameron‐SmithUniversity of Newcastle Australia
Abstract
Background
Red meat is a nutrient-dense food and a dietary staple. A new generation of plant-based meat analogs (PBMAs) have been designed to mimic the experience of eating meat, but there is limited evidence about their digestive efficacy and nutritional quality.
Objectives
We compared the postprandial digestive response of a single meal containing meat commercially raised in New Zealand, including lamb, on-farm pasture-raised beef (Pasture), or grain-finished beef (Grain) with a PBMA (Beyond Burger; Beyond Meat) sold through consumer retail. The primary outcome was the appearance of amino acids in plasma. Secondary outcomes included glucose and insulin, appetite assessment, and anthropometry.
Methods
Thirty healthy men (20-34 y) participated in a double-blinded randomized crossover trial. Each consumed 1 of the 4 test meals on 4 occasions separated by a washout period of at least 1 wk, following an overnight fast. The meal was a burrito-style wrap containing meat or PBMAs, vegetables, salsa, and seasonings in a flour tortilla. The amount of Pasture, Grain, Lamb, or BB was 220 g raw (∼160 g cooked). Venous blood samples were collected over 4 h. Appetite and hunger status was scored with visual analog scales.
Results
Pre-meal amino acid concentrations in plasma did not differ by group (P > 0.9), although several nonessential amino acids differed strongly according to participant BMI. Postprandial amino acids peaked at 2-3 h in all groups. The BB meal produced significantly lower plasma concentrations of total, essential, branched-chain, and non-proteogenic amino acids than the Lamb, Pasture, or Grain meals, based on AUC. There were no significant differences between meal groups in scores for hunger, fullness, or cravings.
Conclusions
Red meat meals exhibited greater bioavailability of amino acids compared with the PBMA (BB). Pasture versus Grain origins of the beef had little influence on participants' responses. This trial was registered at ClinicalTrials.gov as NCT04545398.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY).
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