Associations of the Dietary Magnesium Intake and Magnesium Depletion Score With Osteoporosis Among American Adults: Data From the National Health and Nutrition Examination Survey
Wang J, Xing F, Sheng N, Xiang Z
Frontiers in nutrition · 29 citations
How it was studied
- Design
- Cross-sectional study (classified by our AI screen)
- Studied in
- People
- Main outcome
- Clinical events such as disease or death
Who paid for it
- Funding
- Independent funding
- Government
- National Natural Science Foundation of China
- Government
- Department of Science and Technology of Sichuan Province
- University or hospital
- Sichuan University
- University or hospital
- West China Hospital, Sichuan University
- Grants
- Department of Science and Technology of Sichuan Province (2022YFS0099); West China Hospital, Sichuan University (2019HXFH041); National Natural Science Foundation of China (31870961); Sichuan University (2019HXFH041); National Natural Science Foundation of China (2019HXFH041)
Based on 4 listed funder(s) and full-text disclosure statement.
Publication
- Published
- 2022-05-31 · Front Nutr · vol. 9 · p. 883264
- Publisher
- Frontiers Media
- Cited
- 34 citations · more than 93% of similar papers · 3.2× the field average
- Impact
- Top 10% most cited in its field
- References
- 38 works
- Access
- Open access (journal) · CC-BY
- Research areas
- Magnesium in Health and Disease · Parathyroid Disorders and Treatments · Bone health and osteoporosis research
- Keywords
- National Health and Nutrition Examination Survey, Osteoporosis, Medicine, Confidence interval, Logistic regression, Odds ratio, Linear regression, Demography, Bayesian multivariate linear regression, Internal medicine, Gerontology, Environmental health, Population, Statistics, Mathematics
4 authors
From CN
- Jie WangSichuan University; West China Hospital of Sichuan University
- Fei XingSichuan University; West China Hospital of Sichuan University
- Ning ShengSichuan University; West China Hospital of Sichuan University
- Zhou Xiang · correspondingSichuan University; West China Hospital of Sichuan University
Abstract
Objectives
The study aimed to explore the associations between dietary magnesium (Mg) intake and magnesium depletion score (MDS) among American adults with osteoporosis.
Methods
The continuous data from the National Health and Nutrition Examination Survey 2005-2006, 2007-2008, 2009-2010, 2013-2014, and 2017-2018 were merged to ensure a large and representative sample and a total of 14,566 participants were enrolled for the analysis. The weighted multivariate linear regression model was performed to assess the linear relationship between dietary Mg intake and osteoporosis. Further, the non-linear relationship was also characterized by smooth curve fitting (SCF) and weighted generalized additive model (GAM). In addition, the odds ratios (ORs) and 95% confidence intervals (95% CIs) for associations between the MDS and osteoporosis were assessed by weighted logistic regression models.
Results
After adjusting all covariates, the weighted multivariable linear regression models demonstrated that the dietary Mg intake negatively correlated with osteoporosis, especially in participants aged 55 years or older. In addition, the non-linear relationship characterized by SCF and weighted GAM showed that the dietary Mg intake presented an L-shaped association with osteoporosis among females aged 55 years or older. Moreover, the weighted logistic regression model demonstrated that compared with MDS 0, the OR between MDS ≥3 and osteoporosis was 2.987 (95% CI 1.904, 4.686) in the male-middle intake group. Moreover, compared with MDS 0, the ORs between MDS ≥3 and osteoporosis was 5.666 (95% CI 3.188, 10.069) in the female-low intake group and 1.691 (95% CI 1.394, 2.051) in the female-middle intake group.
Conclusion
The present study indicated that in people with a daily intake of Mg level below the recommended daily intake (RDI), the dietary Mg intake and Mg bioavailability represented by MDS have a negative correlation with osteoporosis. According to the results, the combination of MDS and dietary Mg intake may be more comprehensive and rigorous in screening the population with osteoporosis. Therefore, early monitoring and interventions for osteoporosis may be necessary for those with insufficient dietary Mg intake or high MDS scores.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY).
Community trust
Loading…
How much do you trust this study's findings?
Comments
Sign in to rate, comment on or flag this study.Sign inSomething wrong here?
Flag this study if its information, labels or funding look wrong. An editor reviews every flag.
Sign in to rate, comment on or flag this study.Sign inEducational information about published research. Not medical advice, and not a recommendation to start or stop anything.