Does intermittent fasting impact mental disorders? A systematic review with meta-analysis
Fernández-Rodríguez R, Martínez-Vizcaíno V, Mesas AE, Notario-Pacheco B, Medrano M, Heilbronn LK
Critical reviews in food science and nutrition · 46 citations
How it was studied
- Design
- Meta-analysis (indexed by PubMed)
- Studied in
- People
- Main outcome
- Health markers and function
Who paid for it
- Funding
- Independent funding
- Government
- European Regional Development Fund
- Government
- Spanish Ministry of Universities
- Government
- Spanish Ministry of Education, Culture and Sport
- Grants
- European Regional Development Fund (BEAGAL18/00093)
Based on 3 listed funder(s).
Publication
- Published
- 2022-06-17 · Crit Rev Food Sci Nutr · vol. 63 · issue 32 · pp. 11169–11184
- Publisher
- Taylor & Francis
- Cited
- 57 citations · more than 88% of similar papers · 1.8× the field average
- References
- 73 works
- Access
- Paywalled
- Research areas
- Dietary Effects on Health · Circadian rhythm and melatonin · Diet and metabolism studies
- Keywords
- Anxiety, Mood, Depression (economics), Randomized controlled trial, Medicine, Meta-analysis, Mood disorders, Population, Mental health, Psychiatry, Clinical psychology, Internal medicine, Environmental health
- MeSH
- humans, depression, anxiety, mental disorders, intermittent fasting
6 authors
From ES, CL, BR, AU
- Rubén Fernández‐RodríguezUniversity of Castilla-La Mancha
- Vicente Martínez‐VizcaínoUniversidad Autónoma de Chile; University of Castilla-La Mancha
- Arthur Eumann Mesas · correspondingUniversidade Estadual de Londrina; University of Castilla-La Mancha
- Blanca Notario‐PachecoUniversity of Castilla-La Mancha
- María MedranoUniversidad Pública de Navarra (UPNA); University of Castilla-La Mancha; Universidad de Navarra
- Leonie Kaye HeilbronnThe University of Adelaide
Abstract
Accumulating evidence supports the benefits of intermittent fasting (IF) as a dietary strategy for cardiometabolic health and weight control. However, little is known about the potential implications of IF on mental disorders. The aim of this review was to synthesize evidence regarding the effects of IF on mental disorders (depression, anxiety, and mood state) in the general population. We conducted a systematic search in five databases from inception to January 2022. Randomized and nonrandomized clinical trials (RCTs/nonRCTs) were included. A random effects method was used to pool standardized mean differences (SMDs) and 95% CIs. A total of 14 studies involving 562 individuals were included, of which 8 were RCTs and 6 were nonRCTs. IF showed a moderate and positive effect on depression scores when compared to control groups (SMD: 0.41; 95%CI: 0.05 to 0.76; I2=45%; n = 4). Conversely, within-group analyses did not show any significant effect of IF on anxiety (SMD: 0.10; 95%CI: -0.09 to 0.30; I2=0%; n = 5) or mood state (SMD: 0.14; 95%CI: -0.09 to 0.37; I2=59%; n = 7). IF modalities did not negatively impact mental disorders in the general population. In fact, IF showed a positive influence on diminishing depression scores, and did not modify anxiety or mood.
Abstract via Europe PMC. Copyright remains with the authors or publisher.
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