Funded in part by Egg Nutrition Center
Intake of eggs, choline, lutein, zeaxanthin, and DHA during pregnancy and their relationship to fetal neurodevelopment
Christifano DN, Chollet-Hinton L, Hoyer D, Schmidt A, Gustafson KM
Nutritional neuroscience · 13 citations
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- Cohort study (classified by our AI screen)
- Studied in
- People
- Main outcome
- Health markers and function
- Intake measured by
- Food frequency questionnaire
Who paid for it
- Funding
- Industry funded
- Industry group
- Egg Nutrition Center
- Government
- National Institute of Child Health and Human Development
- Government
- Eunice Kennedy Shriver National Institute of Child Health and Human Development
- Government
- NICHD NIH HHS
- Grants
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (R01 HD086001); National Institute of Child Health and Human Development (1R01HD086001)
Based on 4 listed funder(s).
Publication
- Published
- 2022-06-17 · Nutr Neurosci · vol. 26 · issue 8 · pp. 749–755
- Publisher
- Taylor & Francis
- Cited
- 16 citations · more than 86% of similar papers · 1.9× the field average
- References
- 24 works
- Access
- Open access (repository copy)
- Research areas
- Folate and B Vitamins Research · Gestational Diabetes Research and Management · Birth, Development, and Health
- Keywords
- Choline, Zeaxanthin, Pregnancy, Fetus, Nutrient, Physiology, Lutein, Gestation, Endocrinology, Internal medicine, Medicine, Biology, Animal science, Food science, Carotenoid, Ecology
- MeSH
- humans, choline, lutein, prenatal care, diet, pregnancy, female, zeaxanthins
5 authors
From US, DE
- Danielle Nicole Christifano · correspondingUniversity of Kansas Medical Center
- Lynn Chollet‐HintonUniversity of Kansas Medical Center
- Dirk HoyerJena University Hospital
- Alexander SchmidtJena University Hospital
- Kathleen M. GustafsonUniversity of Kansas Medical Center
Abstract
Background
Maternal intake of eggs and nutrients contained within eggs during pregnancy have the potential to impact fetal neurodevelopment; however, this area is understudied. The purpose of this study was to determine whether maternal egg and choline intake and nutrient interactions between choline, lutein and zeaxanthin (L/Z), and DHA predict fetal neurodevelopment in a large cohort of pregnant women (n = 202). NCT02709239.
Methods
Food frequency questionnaires were used to assess egg and nutrient intake during pregnancy. Fetal neurodevelopment was measured using fetal biomagnetometry at 32 and 36wks gestation, and fetal autonomic indices (SDNN, RMSSD) and brain maturation indices (fABAS) were calculated. Generalized linear models tested the relationships between choline intake, egg intake, and nutrient interactions with fetal neurodevelopment.
Results
Maternal egg intake predicted RMSSD at 32wks and fABAS at 36wks. The interaction between choline and L/Z intake predicted fABAS at 32wks and 36wks and the interaction between choline intake, L/Z intake, and DHA predicted fABAS at 36wks. At 36wks, SDNN was predicted by L/Z intake and interactions between choline and L/Z, L/Z and DHA, and choline, L/Z, and DHA.
Conclusion
Eggs and the nutrients contained within eggs showed synergistic associations with fetal neurodevelopment, and consumption should be encouraged among pregnant women.
Abstract via Europe PMC. Copyright remains with the authors or publisher.
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