Dietary Nitrate Intake Is Associated with Decreased Incidence of Open-Angle Glaucoma: The Rotterdam Study
Vergroesen JE, de Crom TOE, Blekkenhorst LC, Klaver CCW, Voortman T, Ramdas WD
Nutrients · 9 citations
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- Cohort study (indexed by PubMed)
- Studied in
- People
- Main outcome
- Clinical events such as disease or death
- Intake measured by
- Not stated
Who paid for it
- Funding
- Independent funding
- Nonprofit
- Stichting Steunfonds Uitzicht
- Government
- European Commission
- Government
- ZonMw
- University or hospital
- Erasmus Universiteit Rotterdam
- University or hospital
- Erasmus Medisch Centrum
- Government
- Ministerio de Economía y Competitividad
- Nonprofit
- Oogfonds
- Nonprofit
- Landelijke Stichting voor Blinden en Slechtzienden
- Nonprofit
- Stichting Glaucoomfonds
- Nonprofit
- Stichting Lijf en Leven
- Nonprofit
- Stichting voor Ooglijders
- Nonprofit
- Rotterdamse Stichting Blindenbelangen
- Nonprofit
- Stichting Blindenhulp
- Nonprofit
- Rotterdamse Stichting Blindenbelangen (RSB)
- University or hospital
- the Research Institute for Diseases in the Elderly
- Nonprofit
- Henkes stichting
- Government
- Ministry of Health Welfare and Sport
- University or hospital
- Erasmus Medical Center
- Government
- the Municipality of Rotterdam
- University or hospital
- Erasmus University
- Government
- the Ministry of Education, Culture and Science
- University or hospital
- Erasmus MC
- University or hospital
- Erasmus University Rotterdam
- Nonprofit
- Landelijke Stichting voor Blinden en Slechtzienden (LSBS)
- University or hospital
- the Research Institute for Diseases in the Elderly (RIDE)
- Nonprofit
- Henkes stichtingv
- Government
- Netherlands Organisation for Health Research and Development
- Government
- the Ministry for Health, Welfare and Sports
- Government
- Ministry of Education Culture and Science
- Nonprofit
- Stichting Oogfonds Nederland
Based on 30 listed funder(s) and full-text disclosure statement.
Publication
- Published
- 2022-06-15 · Nutrients · vol. 14 · issue 12 · p. 2490
- Publisher
- Multidisciplinary Digital Publishing Institute
- Cited
- 12 citations · more than 84% of similar papers · 1.8× the field average
- References
- 88 works
- Access
- Open access (journal) · CC-BY
- Research areas
- Glaucoma and retinal disorders · Retinal Diseases and Treatments · Ophthalmology and Eye Disorders
- Keywords
- Rotterdam Study, Open angle glaucoma, Incidence (geometry), Nitrate, Medicine, Glaucoma, Ophthalmology, Internal medicine, Chemistry, Prospective cohort study, Mathematics
- MeSH
- humans, vegetables, glaucoma, open-angle, nitrates, nitric oxide, nitrogen oxides, incidence, risk factors, prospective studies, female
6 authors
From NL, AU, CH
- Joëlle E. VergroesenErasmus MC
- Tosca O. E. de CromErasmus MC
- Lauren C. BlekkenhorstEdith Cowan University
- Caroline C. W. KlaverRadboud University Nijmegen; University of Basel; Erasmus MC; Radboud University Medical Center; Institute of Molecular and Clinical Ophthalmology Basel
- Trudy VoortmanErasmus MC; Wageningen University & Research
- Wishal D. Ramdas · correspondingErasmus MC
Abstract
Previous studies suggest that nitric oxide is involved in the regulation of the intraocular pressure (IOP) and in the pathophysiology of open-angle glaucoma (OAG). However, prospective studies investigating the association between dietary nitrate intake, a source of nitric oxide, and incident (i)OAG risk are limited. We aimed to determine the association between dietary nitrate intake and iOAG, and to evaluate the association between dietary nitrate intake and IOP. From 1991 onwards, participants were followed each five years for iOAG in the Rotterdam Study. A total of 173 participants developed iOAG during follow-up. Cases and controls were matched on age (mean ± standard deviation: 65.7 ± 6.9) and sex (%female: 53.2) in a case:control ratio of 1:5. After adjustment for potential confounders, total dietary nitrate intake was associated with a lower iOAG risk (odds ratio (OR) with corresponding 95% confidence interval (95% CI): 0.95 (0.91-0.98) for each 10 mg/day higher intake). Both nitrate intake from vegetables (OR (95% CI): 0.95 (0.91-0.98) for each 10 mg/day higher intake) and nitrate intake from non-vegetable food sources (OR (95% CI): 0.63 (0.41-0.96) for each 10 mg/day higher intake) were associated with a lower iOAG risk. Dietary nitrate intake was not associated with IOP. In conclusion, dietary nitrate intake was associated with a reduced risk of iOAG. IOP-independent mechanisms may underlie the association with OAG.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY).
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