The Effects of Time-Restricted Eating on Metabolism and Gut Microbiota: A Real-Life Study
Ferrocino I, Pellegrini M, D'Eusebio C, Goitre I, Ponzo V, Fadda M, Rosato R, Mengozzi G, Beccuti G, Merlo FD, Rahimi F, Comazzi I, Cocolin L, Ghigo E, Bo S
Nutrients · 31 citations
How it was studied
- Design
- Controlled clinical trial (classified by our AI screen)
- Studied in
- People
- Main outcome
- Health markers and function
Who paid for it
- Funding
- Independent funding
- Nonprofit
- Fondazione Cassa di Risparmio di Civitavecchia
- Nonprofit
- Fondazione Cassa di Risparmio
- Grants
- Fondazione Cassa di Risparmio di Civitavecchia (2020.0772)
Based on 2 listed funder(s) and full-text disclosure statement.
Publication
- Published
- 2022-06-21 · Nutrients · vol. 14 · issue 13 · p. 2569
- Publisher
- Multidisciplinary Digital Publishing Institute
- Cited
- 36 citations · more than 94% of similar papers · 3.5× the field average
- Impact
- Top 10% most cited in its field
- References
- 56 works
- Access
- Open access (journal) · CC-BY
- Research areas
- Dietary Effects on Health · Diet and metabolism studies · Circadian rhythm and melatonin
- Keywords
- Gut flora, Metabolism, Biology, Food science, Medicine, Physiology, Internal medicine, Immunology
- MeSH
- humans, obesity, weight loss, caloric restriction, diet, eating, gastrointestinal microbiome
15 authors
From IT
- Ilario FerrocinoUniversity of Turin
- Marianna PellegriniUniversity of Turin
- Chiara D’EusebioUniversity of Turin
- Ilaria GoitreUniversity of Turin
- Valentina PonzoUniversity of Turin
- Maurizio FaddaAzienda Ospedaliera Citta' della Salute e della Scienza di Torino
Abstract
The metabolic benefits of time-restricted eating (TRE) in humans are statistically significant but not clinically relevant. Few data are available about the effects of TRE on the gut microbiota. We compared the effects of a TRE regimen (12 h feeding; n = 24), on the clinical and dietary variables and gut-microbiota composition in patients with obesity, who were subjected for 12 weeks to the same caloric restriction. Median weight loss was 4.0 kg and 2.2 kg in the TRE and TUE groups, respectively, with a between-group borderline difference (p = 0.049). No significant between-group difference was found in other dietary, anthropometric, or laboratory variables. There were no substantial between-group differences in alpha and beta diversity or gut-microbiota composition. The TRE group showed a significant increase in the frequency of Lachnospiraceae, Parasutterella, and Romboutsia at the study’s end. A TRE regimen induced small changes both in metabolic/dietary variables and in the gut-microbiota composition, with respect to the TUE. The microbial changes we have found were of uncertain clinical significance.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY).
Community trust
Loading…
How much do you trust this study's findings?
Comments
Sign in to rate, comment on or flag this study.Sign inSomething wrong here?
Flag this study if its information, labels or funding look wrong. An editor reviews every flag.
Sign in to rate, comment on or flag this study.Sign inEducational information about published research. Not medical advice, and not a recommendation to start or stop anything.