Effect of Cholecalciferol Supplementation on the Clinical Features and Inflammatory Markers in Hospitalized COVID-19 Patients: A Randomized, Open-Label, Single-Center Study
Karonova TL, Golovatyuk KA, Kudryavtsev IV, Chernikova AT, Mikhaylova AA, Aquino AD, Lagutina DI, Zaikova EK, Kalinina OV, Golovkin AS, Grant WB, Shlyakhto EV
Nutrients · 32 citations
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- Randomized controlled trial (indexed by PubMed)
- Studied in
- People
- Main outcome
- Health markers and function
Who paid for it
- Funding
- Independent funding
- Government
- Ministry of Science and Higher Education of the Russian Federation
- Authors
- At least one author declares a financial tie to industry
- Grants
- Ministry of Science and Higher Education of the Russian Federation (075‐15‐2022‐301)
Based on 1 listed funder(s) and full-text disclosure statement.
Publication
- Published
- 2022-06-23 · Nutrients · vol. 14 · issue 13 · p. 2602
- Publisher
- Multidisciplinary Digital Publishing Institute
- Cited
- 40 citations · more than 96% of similar papers · 4.8× the field average
- Impact
- Top 10% most cited in its field
- References
- 59 works
- Access
- Open access (journal) · CC-BY
- Research areas
- Vitamin D Research Studies · COVID-19 Clinical Research Studies · Dermatological and COVID-19 studies
- Keywords
- Cholecalciferol, Medicine, Gastroenterology, Internal medicine, Coronavirus disease 2019 (COVID-19), Vitamin D and neurology, Randomized controlled trial
- MeSH
- humans, vitamin d deficiency, cholecalciferol, vitamin d, dietary supplements, biomarkers, covid-19 drug treatment
12 authors
From RU, US
- Т. Л. Каронова · correspondingFederal Almazov North-West Medical Research Centre
- Ksenia A. GolovatyukFederal Almazov North-West Medical Research Centre
- Igor Vladimirovich KudryavtsevFederal Almazov North-West Medical Research Centre; Institute of Experimental Medicine
- Alena T. ChernikovaFederal Almazov North-West Medical Research Centre
- Arina A. MikhaylovaFederal Almazov North-West Medical Research Centre
- Arthur D. AquinoFederal Almazov North-West Medical Research Centre
Abstract
Recent studies showed that a low 25-hydroxyvitamin D (25(OH)D) level was associated with a higher risk of morbidity and severe course of COVID-19. Our study aimed to evaluate the effects of cholecalciferol supplementation on the clinical features and inflammatory markers in patients with COVID-19. A serum 25(OH)D level was determined in 311 COVID-19 patients. Among them, 129 patients were then randomized into two groups with similar concomitant medication. Group I (n = 56) received a bolus of cholecalciferol at a dose of 50,000 IU on the first and the eighth days of hospitalization. Patients from Group II (n = 54) did not receive the supplementation. We found significant differences between groups with the preferential increase in serum 25(OH)D level and Δ 25(OH)D in Group I on the ninth day of hospitalization (p < 0.001). The serum 25(OH)D level on the ninth day was negatively associated with the number of bed days (r = −0.23, p = 0.006); we did not observe other clinical benefits in patients receiving an oral bolus of cholecalciferol. Moreover, in Group I, neutrophil and lymphocyte counts were significantly higher (p = 0.04; p = 0.02), while the C-reactive protein level was significantly lower on the ninth day of hospitalization (p = 0.02). Patients with supplementation of 100,000 IU of cholecalciferol, compared to those without supplementation, showed a decrease in the frequencies of CD38++CD27 transitional and CD27−CD38+ mature naive B cells (p = 0.006 and p = 0.02) and an increase in the level of CD27−CD38− DN B cells (p = 0.02). Thus, the rise in serum 25(OH)D level caused by vitamin D supplementation in vitamin D insufficient and deficient patients may positively affect immune status and hence the course of COVID-19.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY).
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