Funded in part by Danone
Whole grain germinated brown rice regulates intestinal immune homeostasis and gastrointestinal hormones in type 2 diabetic patients-a randomized control trial
Ding Q, Ren J, Zhou Y, Bai Z, Yan J, Na G, Shan Y
Food & function · 15 citations
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- Randomized controlled trial (indexed by PubMed)
- Studied in
- People
- Main outcome
- Health markers and function
- Intake measured by
- Not stated
Who paid for it
- Funding
- Industry funded
- Company
- Danone
- Government
- Natural Science Foundation of Zhejiang Province
- Grants
- Natural Science Foundation of Zhejiang Province (LY21H260004); Danone (DIC2016-05)
Based on 2 listed funder(s).
Publication
- Published
- 2022-01-01 · Food Funct · vol. 13 · issue 15 · pp. 8274–8282
- Publisher
- Royal Society of Chemistry
- Cited
- 25 citations · more than 92% of similar papers · 3.6× the field average
- Impact
- Top 10% most cited in its field
- References
- 20 works
- Access
- Paywalled
- Research areas
- GABA and Rice Research · Gut microbiota and health · Nutrition, Genetics, and Disease
- Keywords
- Glycated hemoglobin, Bacteroides, Brown rice, Internal medicine, Type 2 diabetes, Immune system, Hormone, Type 2 Diabetes Mellitus, Glycemic, Feces, Food science, Resistin, Medicine, Endocrinology, Biology, Diabetes mellitus, Immunology, Insulin, Insulin resistance, Bacteria, Adipokine, Microbiology
- MeSH
- humans, diabetes mellitus, type 2, gastrointestinal hormones, blood glucose, homeostasis, aged, middle aged, oryza, whole grains
7 authors
From CN
- Qi DingWenzhou Medical University
- Junli RenHarbin Institute of Technology
- Yingying ZhouWenzhou Medical University
- Zhihuai BaiWenzhou Medical University
- Jielin YanWenzhou Medical University
- Guanqiong NaWenzhou Medical University
Abstract
Background: Whole grains present distinguished benefits to a handful of metabolic syndromes (MetS). However, the preventive effects of germinated brown rice (GBR), a new type of brown rice, on patients with type 2 diabetes (T2DM) are rarely reported. Objectives: To investigate whether replacing 100 g refined white rice (RWR) with equal GBR per day is effective in T2DM and its underlying mechanisms. Methods: Ninety-nine qualified T2DM patients (64.58 ± 5.06 years old) were recruited. All patients were randomly divided into GBR group (100 g d-1 GBR for 12 weeks) and control group (keep the regular diet). Food frequency questionnaires, and fresh stool and serum samples were collected before and after the intervention, followed by various measurements. Results: Fasting blood glucose was obviously decreased after GBR intervention with an effective rate of 62%. Glycated hemoglobin (HbA1c) levels were decreased in the GBR group with no significance. In the GBR group, the abundance of beneficial bacteria in feces was increased, while harmful bacteria were decreased. The percentage of Bacteroides (57.2%) was largely increased. In addition, three types of short-chain fatty acids (SCFAs) including acetic acid, propanoic acid, and butyric acid were increased significantly by GBR (p p Conclusions: GBR (100 g d-1 for 12 weeks) has positive improvement in the fasting blood glucose for T2DM patients, which attributed to the recovery of intestinal homeostasis.
Abstract via Europe PMC. Copyright remains with the authors or publisher.
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