Periconceptional and First Trimester Ultraprocessed Food Intake and Maternal Cardiometabolic Outcomes
Yisahak SF, Hinkle SN, Mumford SL, Gleason JL, Grantz KL, Zhang C, Grewal J
Diabetes care · 7 citations
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- Cohort study (indexed by PubMed)
- Studied in
- People
- Main outcome
- Clinical events such as disease or death
- Intake measured by
- Food frequency questionnaire
Who paid for it
- Funding
- Independent funding
- Nonprofit
- American Diabetes Association
- University or hospital
- Northwestern University
- University or hospital
- University of South Carolina
- Government
- National Institutes of Health
- University or hospital
- University of California, Irvine
- Government
- National Institute of Child Health and Human Development
- Government
- Eunice Kennedy Shriver National Institute of Child Health and Human Development
- Government
- NICHD NIH HHS
- Grants
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (HHSN275200800012C); National Institute of Child Health and Human Development (HHSN275200800013C); Eunice Kennedy Shriver National Institute of Child Health and Human Development (HHSN275200800014C); National Institutes of Health (HHSN27500006); Eunice Kennedy Shriver National Institute of Child Health and Human Development (HHSN275201000009C); National Institutes of Health (HHSN275 200800012C); Eunice Kennedy Shriver National Institute of Child Health and Human Development (HHSN27500006); National Institutes of Health (HHSN275200800028C); National Institute of Child Health and Human Development (HHSN 275200800002I); Eunice Kennedy Shriver National Institute of Child Health and Human Development (HHSN275200800013C); Eunice Kennedy Shriver National Institute of Child Health and Human Development (HHSN275 200800028C); National Institutes of Health (HHSN275200800013C); National Institute of Child Health and Human Development (HHSN27500006); Eunice Kennedy Shriver National Institute of Child Health and Human Development (HHSN275200800002I); National Institutes of Health (HHSN275200800002I); National Institute of Child Health and Human Development (HHSN275200800014C); National Institute of Child Health and Human Development (HHSN275200800028C)
Based on 8 listed funder(s).
Publication
- Published
- 2022-07-19 · Diabetes Care · vol. 45 · issue 9 · pp. 2028–2036
- Publisher
- American Diabetes Association
- Cited
- 22 citations · more than 94% of similar papers · 3.9× the field average
- Impact
- Top 10% most cited in its field
- References
- 37 works
- Access
- Free to read
- Research areas
- Consumer Attitudes and Food Labeling · Gestational Diabetes Research and Management · Cancer Risks and Factors
- Keywords
- Medicine, Pregnancy, Gestational diabetes, Obstetrics, Odds ratio, Quartile, Population, Preeclampsia, Gestational hypertension, Blood pressure, Diabetes mellitus, Body mass index, Glycemic, Gestation, Prospective cohort study, Weight gain, Confounding, Internal medicine, Endocrinology, Confidence interval, Environmental health, Body weight
- MeSH
- humans, diabetes, gestational, hypertension, blood glucose, body mass index, prospective studies, pregnancy, pregnancy trimester, first, eating, female
7 authors
From US, SG
- Samrawit F. YisahakNational Institutes of Health; Office of the Director; Eunice Kennedy Shriver National Institute of Child Health and Human Development
- Stefanie N. HinkleUniversity of Pennsylvania
- Sunni L. MumfordUniversity of Pennsylvania
- Jessica L. GleasonNational Institutes of Health; Eunice Kennedy Shriver National Institute of Child Health and Human Development
- Katherine L. GrantzNational Institutes of Health; Eunice Kennedy Shriver National Institute of Child Health and Human Development
- Cuilin ZhangNational University of Singapore
Abstract
Objective
Ultraprocessed foods (UPFs) have been linked with obesity and cardiometabolic diseases in the general population but are understudied in pregnancy. We examined associations of UPF intake with gestational weight gain (GWG), glycemic, and blood pressure outcomes in pregnancy.
Research design and methods
Pregnant women (n = 1,948) in a prospective U.S. cohort self-reported the past 3-month diet using a food frequency questionnaire (FFQ) at 8-13 weeks of gestation. The intake quantity (g/day) of foods and beverages identified as UPFs was ranked into quartiles. Associations of UPFs were evaluated, after adjusting for confounders, with 2nd and 3rd trimester Institute of Medicine (IOM) GWG categories, gestational diabetes mellitus (GDM), and hypertensive disorders of pregnancy (GHTN). Secondary outcomes included GWG rate, glucose challenge test 1-h glucose, and blood pressure trajectories from linear mixed models.
Results
A total of 492 (25.2%) and 699 women (35.9%) had 2nd and 3rd trimester excessive GWG, respectively, and 85 women (4.4%) had GDM and 63 (3.2%) had severe hypertension or preeclampsia. UPF intake was not associated with higher odds of excessive GWG (quartile 4 vs. 1: adjusted odds ratio 0.68 [95% CI 0.44, 1.05], P-trend = 0.10 for 2nd trimester) or GDM risk (quartile 4 vs. 1: adjusted risk ratio 0.99 [95% CI 0.46, 2.11], P-trend = 0.85). Although UPF intake was positively associated with minor differences blood pressure trajectories, associations with GHTN were null.
Conclusions
The expected unfavorable association of higher UPF intake with excessive GWG, GDM, and GHTN was not observed in our cohort of low-risk pregnant women. These results are based on a limited sample size and require replication.
Abstract via Europe PMC. Copyright remains with the authors or publisher.
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