Funded in part by UCM-Santander
Neuroprotective and Anti-Inflammatory Effects of Linoleic Acid in Models of Parkinson's Disease: The Implication of Lipid Droplets and Lipophagy
Alarcon-Gil J, Sierra-Magro A, Morales-Garcia JA, Sanz-SanCristobal M, Alonso-Gil S, Cortes-Canteli M, Niso-Santano M, Martínez-Chacón G, Fuentes JM, Santos A, Perez-Castillo A
Cells · 71 citations
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- Animal study (classified by our AI screen)
- Studied in
- People, plus animal or lab work
- Main outcome
- Mechanisms only
Who paid for it
- Funding
- Industry funded
- Government
- Comunidad de Madrid
- Government
- European Commission
- Government
- European Regional Development Fund
- Government
- Erasmus+ funding programme
- University or hospital
- Health Institute “Carlos III”-CIBERNED
- Government
- Fondo Europeo de Desarrollo Regional
- Government
- MINECO
- Company
- UCM-Santander
- Grants
- European Regional Development Fund (PR44/21-29931); European Regional Development Fund (SAF2014-52940-R); Comunidad de Madrid (SAF2017-85199-P); Comunidad de Madrid (CB06/05/0041); European Regional Development Fund (SAF2017-85199-P); European Regional Development Fund (CB06/05/0041); Comunidad de Madrid (2015/03); European Regional Development Fund (SAF 2016-78666-R); Comunidad de Madrid (SAF 2016-78666-R); Comunidad de Madrid (PR44/21-29931); European Regional Development Fund (2015/03); European Regional Development Fund (PEJ-2019-AI/SAL-12877); Comunidad de Madrid (PEJ-2019-AI/SAL-12877); Comunidad de Madrid (SAF2014-52940-R)
Based on 8 listed funder(s) and full-text disclosure statement.
Publication
- Published
- 2022-07-26 · Cells · vol. 11 · issue 15 · p. 2297
- Publisher
- Multidisciplinary Digital Publishing Institute
- Cited
- 90 citations · more than 99% of similar papers · 8.3× the field average
- Impact
- Top 10% most cited in its field
- References
- 38 works
- Access
- Open access (journal) · CC-BY
- Research areas
- Lipid metabolism and biosynthesis · Autophagy in Disease and Therapy · Endoplasmic Reticulum Stress and Disease
- Keywords
- Neuroprotection, Autophagy, Lipid metabolism, Parkinson's disease, Oxidative stress, Lipid droplet, Neurodegeneration, Dopaminergic, Pharmacology, Chemistry, Biology, Cell biology, Neuroscience, Medicine, Biochemistry, Dopamine, Disease, Apoptosis, Internal medicine
- MeSH
- cell line, tumor, animals, humans, mice, neuroblastoma, parkinson disease, neurodegenerative diseases, oxidopamine, linoleic acid, autophagy, lipid droplets
11 authors
From ES
- Jesús Alarcón-GilInstituto de Investigaciones Biomédicas Sols-Morreale; Instituto Ramón y Cajal de Investigación Sanitaria; Universidad Autónoma de Madrid
- Ana Sierra‐MagroInstituto de Salud Carlos III; Biomedical Research Networking Center on Neurodegenerative Diseases; Instituto de Investigaciones Biomédicas Sols-Morreale; Centro de Investigación Biomédica en Red; Universidad Autónoma de Madrid
- Jose Angel Morales-GarciaUniversidad Complutense de Madrid; Instituto de Salud Carlos III; Biomedical Research Networking Center on Neurodegenerative Diseases; Instituto de Investigaciones Biomédicas Sols-Morreale; Centro de Investigación Biomédica en Red; Universidad Autónoma de Madrid
- Marina Sanz-SanCristóbalInstituto de Salud Carlos III; Biomedical Research Networking Center on Neurodegenerative Diseases; Instituto de Investigaciones Biomédicas Sols-Morreale; Centro de Investigación Biomédica en Red; Universidad Autónoma de Madrid
- Sandra Alonso‐GilInstituto de Salud Carlos III; Biomedical Research Networking Center on Neurodegenerative Diseases; Instituto de Investigaciones Biomédicas Sols-Morreale; Centro de Investigación Biomédica en Red; Universidad Autónoma de Madrid
- Marta Cortés‐CanteliInstituto de Salud Carlos III; Spanish National Centre for Cardiovascular Research; Biomedical Research Networking Center on Neurodegenerative Diseases; Centro de Investigación Biomédica en Red; Hospital Universitario Fundación Jiménez Díaz
Abstract
Parkinson's disease (PD) is the second most prevalent neurodegenerative disease after Alzheimer's disease. The principal pathological feature of PD is the progressive loss of dopaminergic neurons in the ventral midbrain. This pathology involves several cellular alterations: oxidative stress, mitochondrial dysfunction, loss of proteostasis, and autophagy impairment. Moreover, in recent years, lipid metabolism alterations have become relevant in PD pathogeny. The modification of lipid metabolism has become a possible way to treat the disease. Because of this, we analyzed the effect and possible mechanism of action of linoleic acid (LA) on an SH-SY5Y PD cell line model and a PD mouse model, both induced by 6-hydroxydopamine (6-OHDA) treatment. The results show that LA acts as a potent neuroprotective and anti-inflammatory agent in these PD models. We also observed that LA stimulates the biogenesis of lipid droplets and improves the autophagy/lipophagy flux, which resulted in an antioxidant effect in the in vitro PD model. In summary, we confirmed the neuroprotective effect of LA in vitro and in vivo against PD. We also obtained some clues about the novel neuroprotective mechanism of LA against PD through the regulation of lipid droplet dynamics.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY).
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