Time-restricted eating alters the 24-hour profile of adipose tissue transcriptome in men with obesity
Zhao L, Hutchison AT, Liu B, Wittert GA, Thompson CH, Nguyen L, Au J, Vincent A, Manoogian ENC, Le HD, Williams AE, Banks S, Panda S, Heilbronn LK
Obesity (Silver Spring, Md.) · 32 citations
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- Controlled clinical trial (classified by our AI screen)
- Studied in
- People
- Main outcome
- Health markers and function
Who paid for it
- Funding
- Independent funding
- Nonprofit
- Robert Wood Johnson Foundation
- Nonprofit
- Diabetes Australia Research Trust
- Nonprofit
- Diabetes Australia
- University or hospital
- University of Adelaide
- Government
- National Institutes of Health
- Government
- National Institute of Diabetes and Digestive and Kidney Diseases
- Government
- NIDDK NIH HHS
- Authors
- At least one author declares a financial tie to industry
- Grants
- National Institute of Diabetes and Digestive and Kidney Diseases (R01 DK115214); Robert Wood Johnson Foundation (76014); Diabetes Australia Research Trust (Y18G‐HEIL); Robert Wood Johnson Foundation (DK118278); National Institute of Diabetes and Digestive and Kidney Diseases (R01 DK118278); National Institutes of Health (DK118278); National Institutes of Health (DK115214)
Based on 7 listed funder(s) and full-text disclosure statement.
Publication
- Published
- 2022-08-01 · Obesity (Silver Spring) · vol. 31 · issue S1 · pp. 63–74
- Publisher
- Wiley
- Cited
- 43 citations · more than 96% of similar papers · 4.0× the field average
- Impact
- Top 10% most cited in its field
- References
- 54 works
- Access
- Open access (hybrid journal) · CC-BY-NC
- Research areas
- Dietary Effects on Health · Circadian rhythm and melatonin · Sleep and related disorders
- Keywords
- Endocrinology, Internal medicine, NEFA, PER1, Biology, Circadian rhythm, Adipose tissue, Hormone, Insulin, Circadian clock, Medicine, CLOCK
- MeSH
- adipose tissue, humans, obesity, melatonin, hydrocortisone, fatty acids, nonesterified, circadian rhythm, aged, middle aged, male, insulins, transcriptome, intermittent fasting
14 authors
From AU, US
- Lijun ZhaoSouth Australian Health and Medical Research Institute; The University of Adelaide
- Amy T. HutchisonSouth Australian Health and Medical Research Institute; The University of Adelaide
- Bo LiuSouth Australian Health and Medical Research Institute; The University of Adelaide
- Gary WittertSouth Australian Health and Medical Research Institute; The University of Adelaide
- Campbell Henry ThompsonRoyal Adelaide Hospital; The University of Adelaide
- Leanne NguyenRoyal Adelaide Hospital
Abstract
Objective
Time-restricted eating (TRE) restores circadian rhythms in mice, but the evidence to support this in humans is limited. The objective of this study was to investigate the effects of TRE on 24-hour profiles of plasma metabolites, glucoregulatory hormones, and the subcutaneous adipose tissue (SAT) transcriptome in humans.
Methods
Men (n = 15, age = 63 [4] years, BMI 30.5 [2.4] kg/m2 ) were recruited. A 35-hour metabolic ward stay was conducted at baseline and after 8 weeks of 10-hour TRE. Assessment included 24-hour profiles of plasma glucose, nonesterified fatty acid (NEFA), triglyceride, glucoregulatory hormones, and the SAT transcriptome. Dim light melatonin onset and cortisol area under the curve were calculated.
Results
TRE did not alter dim light melatonin onset but reduced morning cortisol area under the curve. TRE altered 24-hour profiles of insulin, NEFA, triglyceride, and glucose-dependent insulinotropic peptide and increased transcripts of circadian locomotor output cycles protein kaput (CLOCK) and nuclear receptor subfamily 1 group D member 2 (NR1D2) and decreased period circadian regulator 1 (PER1) and nuclear receptor subfamily 1 group D member 1 (NR1D1) at 12:00 am. The rhythmicity of 450 genes was altered by TRE, which enriched in transcripts for transcription corepressor activity, DNA-binding transcription factor binding, regulation of chromatin organization, and small GTPase binding pathways. Weighted gene coexpression network analysis revealed eigengenes that were correlated with BMI, insulin, and NEFA.
Conclusions
TRE restored 24-hour profiles in hormones, metabolites, and genes controlling transcriptional regulation in SAT, which could underpin its metabolic health benefit.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY-NC).
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