The effects of magnesium supplementation on abnormal uterine bleeding, alopecia, quality of life, and acne in women with polycystic ovary syndrome: a randomized clinical trial
Jaripur M, Ghasemi-Tehrani H, Askari G, Gholizadeh-Moghaddam M, Clark CCT, Rouhani MH
Reproductive biology and endocrinology : RB&E · 12 citations
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- Randomized controlled trial (indexed by PubMed)
- Studied in
- People
- Main outcome
- Health markers and function
Who paid for it
- Funding
- Funding not disclosed
Publication
- Published
- 2022-08-02 · Reprod Biol Endocrinol · vol. 20 · issue 1 · p. 110
- Publisher
- BioMed Central
- Cited
- 18 citations · more than 79% of similar papers · 1.4× the field average
- References
- 61 works
- Access
- Open access (journal) · CC-BY
- Research areas
- Magnesium in Health and Disease · Ovarian function and disorders · Preterm Birth and Chorioamnionitis
- Keywords
- Polycystic ovary, Medicine, Acne, Randomized controlled trial, Quality of life (healthcare), Placebo, Internal medicine, Clinical trial, Gynecology, Dermatology, Pathology, Obesity, Alternative medicine, Insulin resistance
- MeSH
- humans, polycystic ovary syndrome, uterine hemorrhage, acne vulgaris, alopecia, magnesium, pregnancy, quality of life, dietary supplements, female, biomarkers
6 authors
From IR, GB
- Mahsima JaripurIsfahan University of Medical Sciences
- Hatav Ghasemi TehraniIsfahan University of Medical Sciences
- Gholamreza AskariIsfahan University of Medical Sciences
- Mahsa Gholizadeh‐MoghaddamIsfahan University of Medical Sciences
- Cain C. T. ClarkCoventry University
- Mohammad Hossein RouhaniIsfahan University of Medical Sciences
Abstract
Background
Abnormal uterine bleeding (AUB), alopecia, low quality of life, and acne are considered as complications of polycystic ovary syndrome (PCOS). We hypothesized that magnesium supplementation would yield beneficial effects on PCOS related complications.
Objective
To examine the effects of magnesium supplementation on AUB, alopecia, quality of life, and acne.
Methods
In this parallel randomized clinical trial, we randomly assigned 64 women with PCOS to the magnesium group (n = 32) or placebo group (n = 32) for 10 weeks. AUB, alopecia, quality of life, and acne were assessed by the International Federation of Gynecology and Obstetrics criterion, the Sinclair Scale, the Health Survey Quality of Life Questionnaire, and the Global Acne Grading System, respectively. This randomized clinical trial was registered at IRCT.ir (IRCT20130903014551N9).
Results
Magnesium supplementation significantly improved the components of quality of life including physical functioning (p = 0.011), role limitations due to physical health (p = 0.012), role limitations due to emotional problems (p < 0.001), energy/fatigue (p = 0.005), emotional wellbeing (p < 0.001), social functioning (p = 0.002), general health (p = 0.013), and total quality of life (p < 0.001), compared with placebo. No significant effect was observed on acne, alopecia, and AUB.
Conclusion
Magnesium supplementation in women with PCOS had a significant positive effect on improving total quality of life.
Trial registration
This randomized clinical trial was registered at IRCT.ir on 2020-10-18 (Registration Code: IRCT20130903014551N9 ).
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY).
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