Effects of the 5:2 intermittent fasting diet on non-alcoholic fatty liver disease: A randomized controlled trial
Kord Varkaneh H, Salehi Sahlabadi A, Găman MA, Rajabnia M, Sedanur Macit-Çelebi M, Santos HO, Hekmatdoost A
Frontiers in nutrition · 61 citations
How it was studied
- Design
- Randomized controlled trial (classified by our AI screen)
- Studied in
- People
- Main outcome
- Health markers and function
Who paid for it
- Funding
- Independent funding
- University or hospital
- Shahid Beheshti University of Medical Sciences
- University or hospital
- National Nutrition and Food Technology Research Institute
- Grants
- Shahid Beheshti University of Medical Sciences (1000328)
Based on 2 listed funder(s) and full-text disclosure statement.
Publication
- Published
- 2022-07-26 · Front Nutr · vol. 9 · p. 948655
- Publisher
- Frontiers Media
- Cited
- 76 citations · more than 98% of similar papers · 7.3× the field average
- Impact
- Top 10% most cited in its field
- References
- 77 works
- Access
- Open access (journal) · CC-BY
- Research areas
- Dietary Effects on Health · Diet and metabolism studies · Liver Disease Diagnosis and Treatment
- Keywords
- Medicine, Internal medicine, Fatty liver, Gastroenterology, Body mass index, Steatosis, Randomized controlled trial, Endocrinology, Disease
7 authors
From IR, RO, TR, BR
- Hamed Kord‐VarkanehNational Nutrition and Food Technology Research Institute; Shahid Beheshti University of Medical Sciences
- Ammar Salehi sahlabadiNational Nutrition and Food Technology Research Institute; Shahid Beheshti University of Medical Sciences
- Mihnea‐Alexandru GămanCarol Davila University of Medicine and Pharmacy; Institutul Clinic Fundeni
- Mohsen RajabniaResearch Institute for Gastroenterology and Liver Diseases; Shahid Beheshti University
- Melahat Sedanur MacitOndokuz Mayıs University
- Heitor Oliveira SantosUniversidade Federal de Uberlândia
Abstract
Background and aims
Dietary regimens are crucial in the management of non-alcoholic fatty liver disease (NAFLD). The effects of intermittent fasting (IF) have gained attention in this regard, but further research is warranted. Thus, we aimed to ascertain the overall effects of the 5:2 IF diet (5 days a week of normal food intake and 2 consecutive fasting days) in patients with NAFLD compared to a control group (usual diet).
Methods and results
A 12-week randomized controlled trial was performed to evaluate the effects of the 5:2 IF diet on anthropometric indices, body composition, liver indices, serum lipids, glucose metabolism, and inflammatory markers in patients with NAFLD. The IF group (n = 21) decreased body weight (86.65 ± 12.57-82.94 ± 11.60 kg), body mass index (30.42 ± 2.27-29.13 ± 1.95 kg/m2), waist circumference (103.52 ± 6.42-100.52 ± 5.64 cm), fat mass (26.64 ± 5.43-23.85 ± 5.85 kg), fibrosis (6.97 ± 1.94-5.58 ± 1.07 kPa), steatosis scores/CAP (313.09 ± 25.45-289.95 ± 22.36 dB/m), alanine aminotransferase (41.42 ± 20.98-28.38 ± 15.21 U/L), aspartate aminotransferase (34.19 ± 10.88-25.95 ± 7.26 U/L), triglycerides (171.23 ± 39.88-128.04 ± 34.88 mg/dl), high-sensitivity C-reactive protein (2.95 ± 0.62 -2.40 ± 0.64 mg/L), and cytokeratin-18 (1.32 ± 0.06-1.19 ± 0.05 ng/ml) values compared to the baseline and the end of the control group (n = 23)-p ≤ 0.05 were considered as significant. However, the intervention did not change the levels of high-density lipoprotein cholesterol, total cholesterol, low-density lipoprotein cholesterol, fasting blood sugar, insulin, HOMA-IR, and total antioxidant capacity.
Conclusion
Adhering to the 5:2 IF diet can reduce weight loss and related parameters (fat mass and anthropometric indicators of obesity), as well as hepatic steatosis, liver enzymes, triglycerides, and inflammatory biomarkers in patients with NAFLD.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY).
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