Effects of whole grain intake on glucagon-like peptide 1 and glucose-dependent insulinotropic peptide: a systematic review and meta-analysis
Hassanzadeh-Rostami Z, Ghobadi S, Faghih S
Nutrition reviews · 3 citations
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- Meta-analysis (indexed by PubMed)
- Studied in
- People
- Main outcome
- Health markers and function
- Intake measured by
- Not stated
Who paid for it
- Funding
- Funding not disclosed
Publication
- Published
- 2022-08-12 · Nutr Rev · vol. 81 · issue 4 · pp. 384–396
- Publisher
- Oxford University Press
- Cited
- 6 citations · more than 36% of similar papers · 0.3× the field average
- References
- 44 works
- Access
- Open access (repository copy) · CC-BY
- Research areas
- Food composition and properties · Celiac Disease Research and Management · Consumer Attitudes and Food Labeling
- Keywords
- Postprandial, Medicine, Internal medicine, Glucagon-like peptide-1, Meta-analysis, Area under the curve, Context (archaeology), Endocrinology, Diabetes mellitus, Type 2 diabetes, Insulin, Biology
- MeSH
- humans, gastric inhibitory polypeptide, insulin, blood glucose, glucagon-like peptide 1, incretins, whole grains
3 authors
From IR
- Zahra Hassanzadeh-RostamiShiraz University of Medical Sciences
- Saeed GhobadiJahrom University of Medical Sciences; Alborz University of Medical Sciences
- Shiva Faghih · correspondingShiraz University of Medical Sciences
Abstract
Context
Whole grain intake may control help glycemia and reduce food intake by affecting the secretion of glucagon-like peptide 1 (GLP-1) and glucose-dependent insulinotropic peptide (GIP).
Objective
This systematic review and meta-analysis aimed to assess the postprandial and long-term effects of whole grains on GLP-1 and GIP levels.
Data sources
PubMed, Web of Science, and Scopus online databases were searched systematically to identify relevant randomized clinical trials (RCTs) published up to April 2021.
Study selection
RCTs that evaluated the effects of whole grains, compared with refined grains, on the postprandial area under the curve (AUC) value, the postprandial serum concentration of incretins from 0 to 180 minutes, or the fasting level of incretins after at least 14 days of intervention were included.
Results
Nineteen studies were included in the meta-analysis. The results showed that acute intake of whole grains could not significantly change the AUC value of GLP-1 or GIP. However, the AUC value of GIP was reduced more significantly in (1) unhealthy participants (standard mean difference [SMD] -1.08; 95%CI, -2.07 to -0.10; I2 = 75.9%) compared with healthy participants, and (2) those with a baseline fasting blood glucose of ≥99 mg/dL (SMD -0.71; 95%CI, -1.30 to -0.11; I2 = 74.4%) compared with those with a baseline value of < 99 mg/dL. On the other hand, the results of time-response evaluation during 0 to 180 minutes after the intake of test meals showed that serum concentrations of GIP decreased significantly from 0 to 30 minutes (coefficient = -44.72; P = 0.005), but increased from 60 to 180 minutes (coefficient = 27.03; P = 0.005). However, long-term studies found no significant effects of whole grains on fasting concentrations of GLP-1 or GIP.
Conclusion
Whole grain intake did not affect postprandial levels of GLP-1 but enhanced postprandial levels of GIP from 60 to 180 minutes. Further high-quality trials are required to assess the long-term effects of whole grain intake on serum levels of incretins.
Systematic review registration
PROSPERO registration no. CRD42021256695.
Abstract via Europe PMC. Copyright remains with the authors or publisher.
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