Creatine Monohydrate Supplementation, but not Creatyl-L-Leucine, Increased Muscle Creatine Content in Healthy Young Adults: A Double-Blind Randomized Controlled Trial
Askow AT, Paulussen KJM, McKenna CF, Salvador AF, Scaroni SE, Hamann JS, Ulanov AV, Li Z, Paluska SA, Beaudry KM, De Lisio M, Burd NA
International journal of sport nutrition and exercise metabolism · 4 citations
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- Randomized controlled trial (indexed by PubMed)
- Studied in
- People
- Main outcome
- Health markers and function
Who paid for it
- Funding
- Funding not disclosed
Publication
- Published
- 2022-08-25 · Int J Sport Nutr Exerc Metab · vol. 32 · issue 6 · pp. 446–452
- Publisher
- Human Kinetics
- Cited
- 10 citations · more than 67% of similar papers · 0.9× the field average
- References
- 31 works
- Access
- Free to read
- Research areas
- Muscle metabolism and nutrition · Diet and metabolism studies · Obesity, Physical Activity, Diet
- Keywords
- Creatine Monohydrate, Creatine, Placebo, Medicine, Internal medicine, Randomized controlled trial, Endocrinology, Animal science, Physical therapy, Biology, Pathology
- MeSH
- muscle, skeletal, humans, amides, creatine, leucine, double-blind method, body composition, dietary supplements, female, male, muscle strength, leukemia, lymphocytic, chronic, b-cell, young adult
12 authors
From US, CA
- Andrew T. AskowUniversity of Illinois Urbana-Champaign
- Kevin J.M. PaulussenUniversity of Illinois Urbana-Champaign
- Colleen F. McKennaUniversity of Illinois Urbana-Champaign
- Amadeo Félix SalvadorUniversity of Illinois Urbana-Champaign
- Susannah E. ScaroniUniversity of Illinois Urbana-Champaign
- Jade S. HamannUniversity of Illinois Urbana-Champaign
Abstract
Creatine (Cr) supplementation is a well-established strategy to enhance gains in strength, lean body mass, and power from a period of resistance training. However, the effectiveness of creatyl-L-leucine (CLL), a purported Cr amide, is unknown. Therefore, the purpose of this study was to assess the effects of CLL on muscle Cr content. Twenty-nine healthy men (n = 17) and women (n = 12) consumed 5 g/day of either Cr monohydrate (n = 8; 28.5 ± 7.3 years, 172.1 ± 11.0 cm, 76.6 ± 10.7 kg), CLL (n = 11; 29.2 ± 9.3 years, 170.3 ± 10.5 cm, 71.9 ± 14.5 kg), or placebo (n = 10; 30.3 ± 6.9 years, 167.8 ± 9.9 cm, 69.9 ± 11.1 kg) for 14 days in a randomized, double-blind design. Participants completed three bouts of supervised resistance exercise per week. Muscle biopsies were collected before and after the intervention for quantification of muscle Cr. Cr monohydrate supplementation which significantly increased muscle Cr content with 14 days of supplementation. No changes in muscle Cr were observed for the placebo or CLL groups. Cr monohydrate supplementation is an effective strategy to augment muscle Cr content while CLL is not.
Abstract via Europe PMC. Copyright remains with the authors or publisher.
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