Randomized controlled trial for time-restricted eating in overweight and obese young adults
Zhang LM, Liu Z, Wang JQ, Li RQ, Ren JY, Gao X, Lv SS, Liang LY, Zhang F, Yin BW, Sun Y, Tian H, Zhu HC, Zhou YT, Ma YX
iScience · 68 citations
How it was studied
- Design
- Randomized controlled trial (classified by our AI screen)
- Studied in
- People
- Main outcome
- Health markers and function
Who paid for it
- Funding
- Independent funding
- Nonprofit
- Chinese Nutrition Society
- Government
- National Natural Science Foundation of China
- Grants
- Chinese Nutrition Society (CNS-Feihe2020B38); National Natural Science Foundation of China (81874264)
Based on 2 listed funder(s) and full-text disclosure statement.
Publication
- Published
- 2022-08-05 · iScience · vol. 25 · issue 9 · p. 104870
- Publisher
- Cell Press
- Cited
- 92 citations · more than 98% of similar papers · 7.4× the field average
- Impact
- Top 10% most cited in its field
- References
- 100 works
- Access
- Open access (journal) · CC-BY-NC-ND
- Research areas
- Dietary Effects on Health · Circadian rhythm and melatonin · Diet and metabolism studies
- Keywords
- Overweight, Leptin, Obesity, Randomized controlled trial, Medicine, Weight loss, Internal medicine, Insulin resistance, Endocrinology, Metabolic syndrome, Blood pressure, Insulin
15 authors
From CN
- Limin ZhangHebei Medical University
- Zhan LiuHebei Medical University
- Jiaqi WangHebei Medical University
- Ruiqiang LiHebei Medical University
- Jing-yi RenHebei Medical University
- Xian GaoHebei Medical University
Abstract
Time-restricted eating (TRE) is known to improve metabolic health, whereas very few studies have compared the effects of early and late TRE (eTRE and lTRE) on metabolic health. Overweight and obese young adults were randomized to 6-h eTRE (eating from 7 a.m. to 1 p.m.) (n = 21), 6-h lTRE (eating from 12 p.m. to 6 p.m.) (n = 20), or a control group (ad libitum intake in a day) (n = 19). After 8 weeks, 6-h eTRE and lTRE produced comparable body weight loss compared with controls. Compared with control, 6-h eTRE reduced systolic blood pressure, mean glucose, fasting insulin, insulin resistance, leptin, and thyroid axis activity, whereas lTRE only reduced leptin. These findings shed light on the promise of 6-h eTRE and lTRE for weight loss. Larger studies are needed to assess the promise of eTRE to yield better thyroid axis modulation and overall cardiometabolic health improvement.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY-NC-ND).
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