Magnesium supplementation and iron status among female students: The intervention study
Milinković N, Zeković M, Dodevska M, Đorđević B, Radosavljević B, Ignjatović S, Ivanović N
Journal of medical biochemistry · 2 citations
How it was studied
- Design
- Controlled clinical trial (classified by our AI screen)
- Studied in
- People
- Main outcome
- Health markers and function
Who paid for it
- Funding
- Independent funding
- Government
- Ministarstvo Prosvete, Nauke i Tehnološkog Razvoja
- Government
- Ministry of Education, Science and Technological Development of the Republic of Serbia
- Grants
- Ministarstvo Prosvete, Nauke i Tehnološkog Razvoja (451-03-68/); Ministarstvo Prosvete, Nauke i Tehnološkog Razvoja (175036); Ministarstvo Prosvete, Nauke i Tehnološkog Razvoja (451–03-68/2020–14/200161); Ministarstvo Prosvete, Nauke i Tehnološkog Razvoja (451-03-68 / 2020-14)
Based on 2 listed funder(s) and full-text disclosure statement.
Publication
- Published
- 2021-12-23 · J Med Biochem · vol. 41 · issue 3 · pp. 316–326
- Publisher
- De Gruyter
- Cited
- 4 citations · more than 60% of similar papers · 0.5× the field average
- References
- 44 works
- Access
- Open access (free to publish) · CC-BY
- Research areas
- Magnesium in Health and Disease · Iron Metabolism and Disorders · Potassium and Related Disorders
- Keywords
- Iron status, Intervention (counseling), Iron supplementation, Medicine, Psychology, Iron deficiency, Physiology, Gerontology, Internal medicine, Anemia, Nursing
7 authors
From RS
- Neda MilinkovićUniversity of Belgrade
- Milica ZekovićUniversity of Belgrade; Centre of Research Excellence in Nutrition and Metabolism
- Margarita S. DodevskaInstitute of Public Health of Serbia
- Brižita ĐorđevićUniversity of Belgrade
- Branimir RadosavljevićUniversity of Belgrade
- Svetlana IgnjatovićUniversity of Belgrade
Abstract
Background
Literature data indicate the benefit of magnesium (Mg) supplementation. The aim of this study was to examine the effect of short-term Mg supplementation on iron status in healthy female participants.
Methods
One hundred healthy female students of the University of Belgrade - Faculty of Pharmacy participated the study during eleven intervention days. Students ingested Mg preparations with the same dose of the active substance. The analysis included the measurement of serum iron, unsaturated iron binding capacity (UIBC), total iron binding capacity (TIBC), total Mg (tMg), ionized Mg (iMg), complete blood count, met-, carboxyand oxy-haemoglobin (metHgb, COHgb, O2Hgb). Transferrin concentrations and percentage of transferrin saturation (SAT) were calculated manually. The association among the analyzed biochemical parameters was examined using polynomial regression. A principal component analysis (PCA) was used for the evaluation of interdependence between the analyzed parameters.
Results
A statistically significant trend for change in O2Hgb (%) by tertiles of iMg concentrations was found (P = 0.029). Serum tMg reached significant positive correlation with the SAT at concentration levels greater than 0.9 mmol/L, after 11 days of intervention (R2=0.116). Ionized Mg in a concentration higher than 0.6 mmol/L is positively correlated with SAT and serum Fe (R2=0.214; 0.199, respectively). PCA revealed variability of 64.7% for two axes after 11 days.
Conclusions
Mg supplementation leads to an improvement in the certain iron status parameters even in individuals with optimal levels of these indices. However, caution should be exercised when supplementing Mg, and laboratory monitoring of the interaction is required.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY).
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