Withania somnifera (L.) Dunal (Ashwagandha) for the possible therapeutics and clinical management of SARS-CoV-2 infection: Plant-based drug discovery and targeted therapy
Singh M, Jayant K, Singh D, Bhutani S, Poddar NK, Chaudhary AA, Khan SU, Adnan M, Siddiqui AJ, Hassan MI, Khan FI, Lai D, Khan S
Frontiers in cellular and infection microbiology · 19 citations
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- Systematic review (classified by our AI screen)
- Main outcome
- Mechanisms only
Who paid for it
- Funding
- Independent funding
- Government
- China Postdoctoral Science Foundation
- Government
- Sichuan Province Science and Technology Support Program
- Grants
- China Postdoctoral Science Foundation (2020M 673187); Sichuan Province Science and Technology Support Program (2021YFH0093)
Based on 2 listed funder(s) and full-text disclosure statement.
Publication
- Published
- 2022-08-15 · Front Cell Infect Microbiol · vol. 12 · p. 933824
- Publisher
- Frontiers Media
- Cited
- 39 citations · more than 98% of similar papers · 9.1× the field average
- Impact
- Top 10% most cited in its field
- References
- 150 works
- Access
- Open access (journal) · CC-BY
- Research areas
- Phytochemicals and Medicinal Plants · SARS-CoV-2 and COVID-19 Research · Diverse Scientific Research Studies
- Keywords
- Withania somnifera, Medicine, Traditional medicine, Pharmacology, Coronavirus, Medicinal plants, Biology, Immunology, Coronavirus disease 2019 (COVID-19), Disease, Infectious disease (medical specialty), Internal medicine, Pathology, Alternative medicine
- MeSH
- humans, withania, plant extracts, antiviral agents, aged, drug discovery, sars-cov-2, covid-19 drug treatment
15 authors
From IN, SA, CN
- Manali SinghInvertis University; Govind Ballabh Pant University of Agriculture and Technology
- Kuldeep JayantIndian Institute of Technology Kharagpur
- Dipti SinghGovind Ballabh Pant University of Agriculture and Technology
- Shivani BhutaniInvertis University
- Nitesh Kumar Poddar · correspondingManipal University Jaipur
- Anis Ahmad ChaudharyImam Mohammad ibn Saud Islamic University
Abstract
Coronavirus disease 2019 (COVID-19) pandemic has killed huge populations throughout the world and acts as a high-risk factor for elderly and young immune-suppressed patients. There is a critical need to build up secure, reliable, and efficient drugs against to the infection of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus. Bioactive compounds of Ashwagandha [Withania somnifera (L.) Dunal] may implicate as herbal medicine for the management and treatment of patients infected by SARS-CoV-2 infection. The aim of the current work is to update the knowledge of SARS-CoV-2 infection and information about the implication of various compounds of medicinal plant Withania somnifera with minimum side effects on the patients' organs. The herbal medicine Withania somnifera has an excellent antiviral activity that could be implicated in the management and treatment of flu and flu-like diseases connected with SARS-CoV-2. The analysis was performed by systematically re-evaluating the published articles related to the infection of SARS-CoV-2 and the herbal medicine Withania somnifera. In the current review, we have provided the important information and data of various bioactive compounds of Withania somnifera such as Withanoside V, Withanone, Somniferine, and some other compounds, which can possibly help in the management and treatment of SARS-CoV-2 infection. Withania somnifera has proved its potential for maintaining immune homeostasis of the body, inflammation regulation, pro-inflammatory cytokines suppression, protection of multiple organs, anti-viral, anti-stress, and anti-hypertensive properties. Withanoside V has the potential to inhibit the main proteases (Mpro) of SARS-CoV-2. At present, synthetic adjuvant vaccines are used against COVID-19. Available information showed the antiviral activity in Withanoside V of Withania somnifera, which may explore as herbal medicine against to SARS-CoV-2 infection after standardization of parameters of drug development and formulation in near future.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY).
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