The effect of dietary nitrate on macro- and microvascular function: A systematic review
Volino-Souza M, Oliveira GV, Pinheiro VDS, Conte-Junior CA, Alvares TDS
Critical reviews in food science and nutrition · 11 citations
How it was studied
- Design
- Systematic review (indexed by PubMed)
- Studied in
- People
- Main outcome
- Health markers and function
- Intake measured by
- Not stated
Who paid for it
- Funding
- Independent funding
- Government
- by CAPES (Brazil) and FAPERJ
- Government
- FAPERJ Young Scientist
Based on 2 listed funder(s).
Publication
- Published
- 2022-09-05 · Crit Rev Food Sci Nutr · vol. 64 · issue 5 · pp. 1225–1236
- Publisher
- Taylor & Francis
- Cited
- 15 citations · more than 46% of similar papers · 0.4× the field average
- References
- 68 works
- Access
- Paywalled
- Research areas
- Nitric Oxide and Endothelin Effects · Cardiovascular Health and Disease Prevention · Cerebrovascular and Carotid Artery Diseases
- Keywords
- Nitrate, Ingestion, Bioavailability, Nitric oxide, Dietary Nitrate, Function (biology), Chemistry, Physiology, Internal medicine, Medicine, Nitrite, Pharmacology, Biochemistry, Biology
- MeSH
- humans, nitrates, nitric oxide, diet, dietary supplements, microvessels
5 authors
From BR
- Mônica Volino‐SouzaUniversidade Federal do Rio de Janeiro
- Gustavo Vieira de OliveiraUniversidade Federal do Rio de Janeiro; Fundação Carlos Chagas Filho de Amparo à Pesquisa do Estado do Rio de Janeiro
- Vivian dos Santos PinheiroUniversidade Federal do Rio de Janeiro
- Carlos Adam Conte‐JúniorUniversidade Federal do Rio de Janeiro; Fundação Carlos Chagas Filho de Amparo à Pesquisa do Estado do Rio de Janeiro
- Thiago Silveira Álvares · correspondingUniversidade Federal do Rio de Janeiro
Abstract
Previous studies have investigated the impact of dietary nitrate on vascular function due to the association between dietary nitrate ingestion and improvement in nitric oxide (NO) bioavailability. Considering that NO can present different effects through vascular beds (macro- vs. microvasculature) due to the specific characteristic (function and morphology) that each vessel exhibits, it is crucial to investigate the effect of dietary nitrate ingestion on the macro- and microvascular function to understand the effect of nitrate on vascular function. For this reason, this review aimed to evaluate the impact of dietary nitrate on macro- and microvascular function in humans. A total of 29 studies were included in the systematic review, of which 19 studies evaluated the effect of nitrate supplementation on macrovascular function, eight studies evaluated the effect on microvascular function, and two studies evaluated the impact on both macro- and microvascular function. The literature suggests that dietary nitrate ingestion seems to improve the vascular function in macrovasculature, whereas microvascular function appears to be modest. Future studies investigating the effect of nitrate ingestion on vascular function should focus on measuring macro- and microvascular function whenever possible so that the impact of nitrate-rich foods on vascular segments could be better understood.
Abstract via Europe PMC. Copyright remains with the authors or publisher.
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