Associations of red and processed meat intake with screen-detected colorectal lesions
Kværner AS, Birkeland E, Vinberg E, Hoff G, Hjartåker A, Rounge TB, Berstad P
The British journal of nutrition · 4 citations
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- Cross-sectional study (classified by our AI screen)
- Studied in
- People
- Main outcome
- Clinical events such as disease or death
- Intake measured by
- Food frequency questionnaire
Who paid for it
- Funding
- Independent funding
- Nonprofit
- Kreftforeningen
- Government
- Norges Forskningsråd
Based on 2 listed funder(s) and full-text disclosure statement.
Publication
- Published
- 2022-09-07 · Br J Nutr · vol. 129 · issue 12 · pp. 2122–2132
- Publisher
- Cambridge University Press
- Cited
- 8 citations · more than 69% of similar papers · 0.7× the field average
- References
- 57 works
- Access
- Open access (hybrid journal) · CC-BY
- Research areas
- Colorectal Cancer Screening and Detection · Nutritional Studies and Diet
- Keywords
- Red meat, Medicine, Colonoscopy, White meat, Colorectal cancer, Internal medicine, Gastroenterology, Food science, Pathology, Cancer, Biology
- MeSH
- humans, colorectal neoplasms, colonoscopy, occult blood, diet, meat, meat products, aged, middle aged, norway, female, male, early detection of cancer, red meat
7 authors
From NO
- Ane Sørlie Kværner · correspondingCancer Registry of Norway
- Einar Elvbakken BirkelandUniversity of Oslo; Cancer Registry of Norway
- Elina VinbergCancer Registry of Norway
- Geir S. HoffTelemark Hospital; Cancer Registry of Norway
- Anette HjartåkerUniversity of Oslo
- Trine B. RoungeUniversity of Oslo; Cancer Registry of Norway
Abstract
Limited data exist regarding the role of meat consumption in early-stage colorectal carcinogenesis. We examined associations of red and processed meat intake with screen-detected colorectal lesions in immunochemical fecal occult blood test (FIT)-positive participants, enrolled in the Norwegian CRCbiome study during 2017-2021, aged 55-77 years. Absolute and energy-adjusted intakes of red and processed meat (combined and individually) were assessed using a validated, semi-quantitative FFQ. Associations between meat intake and screen-detected colorectal lesions were examined using multinomial logistic regression analyses with adjustment for key covariates. Of 1162 participants, 319 presented with advanced colorectal lesions at colonoscopy. High v. low energy-adjusted intakes of red and processed meat combined, as well as red meat alone, were borderline to significantly positively associated with advanced colorectal lesions (OR of 1·24 (95 % CI 0·98, 1·57) and 1·34 (95 % CI 1·07, 1·69), respectively). A significant dose-response relationship was also observed for absolute intake levels (OR of 1·32 (95 % CI 1·09, 1·60) per 100 g/d increase in red and processed meat). For processed meat, no association was observed between energy-adjusted intakes and advanced colorectal lesions. A significant positive association was, however, observed for participants with absolute intake levels ≥ 100 v. < 50 g/d (OR of 1·19 (95 % CI 1·09, 1·31)). In summary, high intakes of red and processed meat were associated with presence of advanced colorectal lesions at colonoscopy in FIT-positive participants. The study demonstrates a potential role of dietary data to improve the performance of FIT-based screening.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY).
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