The association of ultra-processed food consumption with adult mental health disorders: a systematic review and dose-response meta-analysis of 260,385 participants
Mazloomi SN, Talebi S, Mehrabani S, Bagheri R, Ghavami A, Zarpoosh M, Mohammadi H, Wong A, Nordvall M, Kermani MAH, Moradi S
Nutritional neuroscience · 46 citations
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- Meta-analysis (indexed by PubMed)
- Studied in
- People
- Main outcome
- Clinical events such as disease or death
- Intake measured by
- Food frequency questionnaire
Who paid for it
- Funding
- Funding not disclosed
Publication
- Published
- 2022-09-12 · Nutr Neurosci · vol. 26 · issue 10 · pp. 913–931
- Publisher
- Taylor & Francis
- Cited
- 80 citations · more than 94% of similar papers · 3.5× the field average
- Impact
- Top 10% most cited in its field
- References
- 91 works
- Access
- Paywalled
- Research areas
- Consumer Attitudes and Food Labeling · Culinary Culture and Tourism · Consumer Packaging Perceptions and Trends
- Keywords
- Medicine, Meta-analysis, Depression (economics), Relative risk, Observational study, Anxiety, Mental health, Calorie, Internal medicine, Environmental health, Confidence interval, Psychiatry
- MeSH
- humans, diet, diet surveys, mental health, energy intake, adult, fast foods, food, processed
11 authors
From IR, US
- Seyadeh Narges MazloomiMazandaran University of Medical Sciences
- Sepide TalebiUniversity of Tehran
- Sanaz MehrabaniIsfahan University of Medical Sciences
- Reza BagheriUniversity of Isfahan
- Abed GhavamiIsfahan University of Medical Sciences
- Mahsa ZarpooshKermanshah University of Medical Sciences
Abstract
Objective
We aimed to conduct a systematic review and meta-analysis of observational studies examining the relationship between ultra-processed food (UPF) consumption and the risk of mental health disorders.
Methods
The ISI Web of Science, PubMed/MEDLINE, and Scopus databases were searched without date restriction until 28 December 2021. Data were extracted from 26 studies, including 260,385 participants from twelve countries. Risk ratios for mental health disorders were pooled by a random-effects model.
Results
Meta-analyses suggested that UPF consumption was associated with an increased risk of depression (RR = 1.28; 95% CI: 1.19, 1.38; I2 = 61.8%; p = 0.022) but not anxiety (RR = 1.35; 95% CI: 0.86, 2.11; I2 = 77.8%; p = 0.198). However, when analyzed for the dietary assessment method, UPF consumption was significantly associated with an enhanced risk of depression among studies utilizing food frequency questionnaires (RR = 1.31; 95% CI: 1.21, 1.41; I2 = 60.0%; p 2 = 88.9%; p p < 0.001).
Conclusion
Our findings indicate that UPF consumption is related to an enhanced depressive mental health status risk. There may be different causes for this increased risk, and further studies are needed to investigate if there is a causal relationship between consumption of UPF and mental health.
Abstract via Europe PMC. Copyright remains with the authors or publisher.
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