Funded in part by Pfizer, GlaxoSmithKline, Novartis, Merck Research Laboratories and GlaxoSmithKline
Whole grain consumption and risk of radiographic knee osteoarthritis: a prospective study from the Osteoarthritis Initiative
Liu T, Xu C, Driban JB, Liang GY, Zhang XH, Hu FB, McAlindon T, Lu B
Rheumatology (Oxford, England) · 7 citations
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- Cohort study (indexed by PubMed)
- Studied in
- People
- Main outcome
- Clinical events such as disease or death
- Intake measured by
- Food frequency questionnaire
Who paid for it
- Funding
- Industry funded
- Government
- U.S. Department of Health and Human Services
- Company
- Pfizer
- Company
- GlaxoSmithKline
- Company
- Novartis
- University or hospital
- Tufts Medical Center
- Government
- National Institutes of Health
- Government
- National Heart, Lung, and Blood Institute
- Government
- National Institute of Arthritis and Musculoskeletal and Skin Diseases
- Government
- NIAMS NIH HHS
- Company
- Merck Research Laboratories and GlaxoSmithKline
- Government
- NIH
- Government
- Department of Health and Human Services
- Government
- NIH HHS
- University or hospital
- Tupper Research Fund at Tufts Medical Center
- Government
- NHLBI NIH HHS
- Grants
- U.S. Department of Health and Human Services (N01-AR-2-2258); U.S. Department of Health and Human Services (N01-AR-2-2261); National Institute of Arthritis and Musculoskeletal and Skin Diseases (N01 ‐ AR ‐ 2 ‐ 2261); U.S. Department of Health and Human Services (N01-AR-2-2262); National Institute of Arthritis and Musculoskeletal and Skin Diseases (N01‐AR‐2‐2260); National Institutes of Health (N01 AR‐2‐2260); National Institutes of Health (N01-AR-2-2258); National Institute of Arthritis and Musculoskeletal and Skin Diseases (N01-AR-2- 2262); National Institute of Arthritis and Musculoskeletal and Skin Diseases (R01 AR074447); National Heart, Lung, and Blood Institute (N01AR22258); U.S. Department of Health and Human Services (N01-AR-2-2259); National Institutes of Health (N01‐AR‐2‐2259); National Institute of Arthritis and Musculoskeletal and Skin Diseases (R01 AR074447 A1); U.S. Department of Health and Human Services (N01-AR-2-2260); National Institutes of Health (N01-AR-2-2261); National Institute of Arthritis and Musculoskeletal and Skin Diseases (N01AR22259); Pfizer (N01-AR-2-2262); GlaxoSmithKline (N01-AR-2-2262); National Institutes of Health (N01-AR-2-2262)
Based on 15 listed funder(s).
Publication
- Published
- 2022-09-21 · Rheumatology (Oxford) · vol. 62 · issue 5 · pp. 1834–1840
- Publisher
- Oxford University Press
- Cited
- 11 citations · more than 84% of similar papers · 1.8× the field average
- References
- 50 works
- Access
- Open access (repository copy)
- Research areas
- Nutritional Studies and Diet · Food composition and properties · Celiac Disease Research and Management
- Keywords
- Medicine, Osteoarthritis, Quartile, Hazard ratio, Prospective cohort study, Incidence (geometry), Internal medicine, Proportional hazards model, Confidence interval, Pathology
- MeSH
- knee joint, humans, osteoarthritis, knee, diet, risk factors, prospective studies, aged, middle aged, whole grains
8 authors
From US, CN
- Tong LiuBrigham and Women's Hospital; Harvard University; Lanzhou University
- Chang Qing XuRutgers, The State University of New Jersey; Brigham and Women's Hospital; Harvard University
- Jeffery B DribanTufts Medical Center
- Geyu LiangSoutheast University
- Xuehong ZhangBrigham and Women's Hospital; Harvard University
- Frank B. HuBrigham and Women's Hospital; Harvard University
Abstract
Objectives
To assess the association of whole grain consumption with the risk of incident knee OA.
Material and methods
We followed 2846 participants in the Osteoarthritis Initiative ages 45-79 years. Participants were free from radiographic knee OA (Kellgren-Lawrence grade <2) in at least one knee at baseline. Dietary data from baseline were obtained using the Block Brief Food Frequency Questionnaire. We defined radiographic knee OA incidence as a Kellgren-Lawrence grade ≥2 during the subsequent 96 months. Cox proportional hazards models were used to assess the association between whole grain food intake and the risk of incident knee OA.
Results
During the 96 month follow-up, 518 participants (691 knees) developed incident radiographic knee OA. Higher total whole grain consumption was significantly associated with a lower knee OA risk [hazard ratio (HR)quartile 4vs1 = 0.66 (95% CI 0.52, 0.84), P for trend < 0.01] after adjusting for demographic and socio-economic factors, clinical factors and other dietary factors related to OA. Consistently, a significant inverse association of dark bread consumption with knee OA risk was observed [HRquartile 4vs1 = 0.68 (95% CI 0.53, 0.87), P for trend < 0.01). In addition, we observed a significant inverse association between higher cereal fibre intake and reduced knee OA risk [HRquartile 4vs1 = 0.61 (95% CI 0.46, 0.81), P for trend < 0.01).
Conclusions
Our findings revealed a significant inverse association of whole grain consumption with knee OA risk. These findings provide evidence that eating a diet rich in whole grains may be a potential nutritional strategy to prevent knee OA.
Abstract via Europe PMC. Copyright remains with the authors or publisher.
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